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The mechanism of sister chromatid cohesion
Experimental Cell Research, 2004Each of our cells inherit their genetic information in the form of chromosomes from a mother cell. In order that we obtain the full genetic complement, cells need to ensure that replicated chromosomes are accurately split and distributed during cell division. Mistakes in this process lead to aneuploidies, cells with supernumerous or missing chromosomes.
Frank Uhlmann
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A matter of choice: the establishment of sister chromatid cohesion [PDF]
EMBO Reports, 2009 Sister chromatid cohesion is the basis for the recognition of chromosomal DNA replication products for their bipolar segregation in mitosis. Fundamental to sister chromatid cohesion is the ring-shaped cohesin complex, which is loaded onto chromosomes long before the initiation of DNA replication and is thought to hold replicated sister chromatids ...
Frank Uhlmann
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Sister chromatid cohesion and recombination in meiosis
Chromosoma, 2000Sister chromatids are associated from their formation until their disjunction. Cohesion between sister chromatids is provided by protein complexes, of which some components are conserved across the kingdoms and between the mitotic and meiotic cell cycles.
C Heyting, Heyting Christa
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Sister chromatid cohesion in mitosis
Current Opinion in Genetics & Development, 1998Sister chromatid cohesion is essential for accurate chromosome segregation during the cell cycle. Newly identified structural proteins are required for sister chromatid cohesion and there may be a link in some organisms between the processes of cohesion and condensation.
S, Biggins, A W, Murray
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SISTER-CHROMATID COHESION IN MITOSIS AND MEIOSIS
Annual Review of Genetics, 1994CYTOLOGY OF SISTER-CHROMATID COHESION Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Roles of Sister-Chromatid Cohesion . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Spatial Diff erences in Chromosome Associations . . . . . . . . . . . . .
W Y, Miyazaki, T L, Orr-Weaver
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The Molecular Basis of Sister-Chromatid Cohesion
Annual Review of Cell and Developmental Biology, 2001▪ Abstract  The replicated copies of each chromosome, the sister chromatids, are attached prior to their segregation in mitosis and meiosis. This association or cohesion is critical for each sister chromatid to bind to microtubules from opposite spindle poles and thus segregate away from each other at anaphase of mitosis or meiosis II.
J Y, Lee, T L, Orr-Weaver
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The regulation of sister chromatid cohesion
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2008Sister chromatid cohesion is a major feature of the eukaryotic chromosome. It entails the formation of a physical linkage between the two copies of a chromosome that result from the duplication process. This linkage must be maintained until chromosome segregation takes place in order to ensure the accurate distribution of the genomic information ...
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Heterochromatin and the cohesion of sister chromatids
Chromosome Research, 2009Heterochromatin, once thought to be the useless junk of chromosomes, is now known to play significant roles in biology. Underlying much of this newfound fame are links between the repressive chromatin structure and cohesin, the protein complex that mediates sister chromatid cohesion.
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Calpain 2 is required for sister chromatid cohesion
Chromosoma, 2010Calpains form a family of Ca(2+)-dependent cysteine proteases involved in diverse cellular processes. However, the specific functions of each calpain isoform remain unknown. Recent reports have shown that calpain 2 (Capn2) is essential for cell viability. We have recently shown that Capn2 is a nuclear protease associated with chromosomes during mitosis
Magnaghi-Jaulin, Laura +5 more
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