Results 141 to 150 of about 10,437 (162)

Sister Chromatid Cohesion Control and Aneuploidy

Cytogenetic and Genome Research, 2011
Apart from a personal tragedy, could Down syndrome, cancer and infertility possibly have something in common? Are there links between a syndrome with physical and mental problems, a tumor growing out of control and the incapability to reproduce? These questions can be answered if we look at the biological functions of a protein complex, named cohesin ...
openaire   +2 more sources

A Molecular Determinant for the Establishment of Sister Chromatid Cohesion

Science, 2008
Chromosome segregation, transcriptional regulation, and repair of DNA double-strand breaks require the cohesin protein complex. Cohesin holds the replicated chromosomes (sister chromatids) together to mediate sister chromatid cohesion. The mechanism of how cohesion is established is unknown.
Elçin, Unal, Jill M, Heidinger-Pauli, Woong, Kim, Vincent, Guacci, Itay, Onn, Steven P, Gygi, Douglas E, Koshland   +6 more
openaire   +2 more sources

Analyzing Sister Chromatid Cohesion in Mammalian Cells

2014
The metaphase chromosome spread technique and subsequent analysis of sister chromatid cohesion is used for (clinical) diagnosis of genetic abnormalities that can cause aberrant sister chromatid cohesion. In addition, the technique can be used to assess the contribution of novel genes to the cohesion establishment and maintenance pathways.
Katherine M, Feeney, Laura, McFarlane-Majeed, Joanna L, Parish   +2 more
openaire   +2 more sources

Sister chromatid cohesion along arms and at centromeres

Trends in Genetics, 2005
There is an obvious difference between the regulation of sister chromatid cohesion at centromeres and along chromosome arms during meiosis, because centromeric cohesion, but not arm cohesion, persists throughout anaphase of the first meiotic division. This regional difference of sister chromatid cohesion is also observed during mitosis; the cohesion is
openaire   +2 more sources

Buck the establishment: reinventing sister chromatid cohesion

Trends in Cell Biology, 2010
The time between chromosome replication and segregation can be from hours to decades. Cohesion is thus crucial for identifying replication products as sister chromatids from S-phase until mitosis. Early models posited active sister chromatid tethering reactions in which cohesins deposited onto each sister chromatid are converted to a paired state by ...
openaire   +2 more sources

Proteins controlling sister-chromatid cohesion

1997
Prior to the metaphase/anaphase transition of cell division the replicated copies of each chromosome, the sister chromatids, are attached to each other. We use the term ‘sister-chromatid cohesion’ to describe this physical association between the sister chromatids.
T. L. Orr-Weaver, D. P. Moore, A. W. Kerrebrock, S. E. Bickel, D. W. Wyman   +4 more
openaire   +1 more source

Cohesion by topology: sister chromatids interlocked by DNA.

Genes & development, 2008
Sister chromatid cohesion is coupled with chromosome replication and influences chromosome segregation and intra-S repair. Specialized proteins, the cohesins, together with other pathways contribute to tether sister chromatids. In this issue of Genes & Development, Wang and colleagues (pp. 2426-2433 demonstrate that TopoIV, a type II DNA topoisomerase,
R. Bermejo, D. Branzei, M. Foiani
openaire   +2 more sources

Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism

EMBO Journal, 2001
Zhonglin Hao, Hiroto Okayama
exaly  

Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase

Molecular Cell, 2017
Shuyu Li, Tomoyuki U Tanaka
exaly  

Sororin pre‐ mRNA splicing is required for proper sister chromatid cohesion in human cells

EMBO Reports, 2014
Erwan Watrin, Claude Prigent
exaly