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Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion.

open access: yesCurr Biol, 2018
Silva RD   +5 more
europepmc   +1 more source
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The mechanism of sister chromatid cohesion

Experimental Cell Research, 2004
Each of our cells inherit their genetic information in the form of chromosomes from a mother cell. In order that we obtain the full genetic complement, cells need to ensure that replicated chromosomes are accurately split and distributed during cell division. Mistakes in this process lead to aneuploidies, cells with supernumerous or missing chromosomes.
Frank Uhlmann
exaly   +3 more sources

A matter of choice: the establishment of sister chromatid cohesion [PDF]

open access: yesEMBO Reports, 2009
Sister chromatid cohesion is the basis for the recognition of chromosomal DNA replication products for their bipolar segregation in mitosis. Fundamental to sister chromatid cohesion is the ring-shaped cohesin complex, which is loaded onto chromosomes long before the initiation of DNA replication and is thought to hold replicated sister chromatids ...
Frank Uhlmann
exaly   +3 more sources

Sister chromatid cohesion in mitosis

Current Opinion in Genetics & Development, 1998
Sister chromatid cohesion is essential for accurate chromosome segregation during the cell cycle. Newly identified structural proteins are required for sister chromatid cohesion and there may be a link in some organisms between the processes of cohesion and condensation.
S, Biggins, A W, Murray
openaire   +3 more sources

SISTER-CHROMATID COHESION IN MITOSIS AND MEIOSIS

Annual Review of Genetics, 1994
CYTOLOGY OF SISTER-CHROMATID COHESION Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Roles of Sister-Chromatid Cohesion . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Spatial Diff erences in Chromosome Associations . . . . . . . . . . . . .
W Y, Miyazaki, T L, Orr-Weaver
openaire   +3 more sources

The Molecular Basis of Sister-Chromatid Cohesion

Annual Review of Cell and Developmental Biology, 2001
▪ Abstract  The replicated copies of each chromosome, the sister chromatids, are attached prior to their segregation in mitosis and meiosis. This association or cohesion is critical for each sister chromatid to bind to microtubules from opposite spindle poles and thus segregate away from each other at anaphase of mitosis or meiosis II.
J Y, Lee, T L, Orr-Weaver
openaire   +2 more sources

The regulation of sister chromatid cohesion

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2008
Sister chromatid cohesion is a major feature of the eukaryotic chromosome. It entails the formation of a physical linkage between the two copies of a chromosome that result from the duplication process. This linkage must be maintained until chromosome segregation takes place in order to ensure the accurate distribution of the genomic information ...
openaire   +2 more sources

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