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Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication [PDF]

Molecular Cell
Concomitant with DNA replication, the ring-shaped cohesin complex encircles both newly synthesized sister chromatids, enabling their faithful segregation during cell divisions.
John Diffley, Frank Uhlmann, Masashi Minamino   +2 more
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The Molecular Basis of Sister-Chromatid Cohesion

Annual Review of Cell and Developmental Biology, 2001
▪ Abstract  The replicated copies of each chromosome, the sister chromatids, are attached prior to their segregation in mitosis and meiosis. This association or cohesion is critical for each sister chromatid to bind to microtubules from opposite spindle poles and thus segregate away from each other at anaphase of mitosis or meiosis II.
J Y, Lee, T L, Orr-Weaver
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Sister chromatid cohesion is mediated by individual cohesin complexes [PDF]

Science
Eukaryotic genomes are organized by loop extrusion and sister chromatid cohesion, both mediated by the multimeric cohesin protein complex. Understanding how cohesin holds sister DNAs together, and how loss of cohesion causes age-related infertility in ...
Kim Nasmyth, Lothar Schermelleh, Fena Ochs   +2 more
exaly   +3 more sources

The regulation of sister chromatid cohesion

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2008
Sister chromatid cohesion is a major feature of the eukaryotic chromosome. It entails the formation of a physical linkage between the two copies of a chromosome that result from the duplication process. This linkage must be maintained until chromosome segregation takes place in order to ensure the accurate distribution of the genomic information ...
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Heterochromatin and the cohesion of sister chromatids

Chromosome Research, 2009
Heterochromatin, once thought to be the useless junk of chromosomes, is now known to play significant roles in biology. Underlying much of this newfound fame are links between the repressive chromatin structure and cohesin, the protein complex that mediates sister chromatid cohesion.
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A Molecular Determinant for the Establishment of Sister Chromatid Cohesion

Science, 2008
Chromosome segregation, transcriptional regulation, and repair of DNA double-strand breaks require the cohesin protein complex. Cohesin holds the replicated chromosomes (sister chromatids) together to mediate sister chromatid cohesion. The mechanism of how cohesion is established is unknown.
Elçin, Unal, Jill M, Heidinger-Pauli, Woong, Kim, Vincent, Guacci, Itay, Onn, Steven P, Gygi, Douglas E, Koshland   +6 more
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Sister chromatid cohesion along arms and at centromeres

Trends in Genetics, 2005
There is an obvious difference between the regulation of sister chromatid cohesion at centromeres and along chromosome arms during meiosis, because centromeric cohesion, but not arm cohesion, persists throughout anaphase of the first meiotic division. This regional difference of sister chromatid cohesion is also observed during mitosis; the cohesion is
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Proteins controlling sister-chromatid cohesion

1997
Prior to the metaphase/anaphase transition of cell division the replicated copies of each chromosome, the sister chromatids, are attached to each other. We use the term ‘sister-chromatid cohesion’ to describe this physical association between the sister chromatids.
T. L. Orr-Weaver, D. P. Moore, A. W. Kerrebrock, S. E. Bickel, D. W. Wyman   +4 more
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Buck the establishment: reinventing sister chromatid cohesion

Trends in Cell Biology, 2010
The time between chromosome replication and segregation can be from hours to decades. Cohesion is thus crucial for identifying replication products as sister chromatids from S-phase until mitosis. Early models posited active sister chromatid tethering reactions in which cohesins deposited onto each sister chromatid are converted to a paired state by ...
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Cohesion by topology: sister chromatids interlocked by DNA.

Genes & development, 2008
Sister chromatid cohesion is coupled with chromosome replication and influences chromosome segregation and intra-S repair. Specialized proteins, the cohesins, together with other pathways contribute to tether sister chromatids. In this issue of Genes & Development, Wang and colleagues (pp. 2426-2433 demonstrate that TopoIV, a type II DNA topoisomerase,
R. Bermejo, D. Branzei, M. Foiani
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