Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2. [PDF]
PLoS Genetics, 2019 Cohesin acetyltransferases ESCO1 and ESCO2 play a vital role in establishing sister chromatid cohesion. How ESCO1 and ESCO2 are controlled in a DNA replication-coupled manner remains unclear in higher eukaryotes. Here we show a critical role of CUL4-RING
Haitao Sun +7 more
doaj +2 more sources
SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis [PDF]
Nature Communications, 2019 During cell division, Soronin antagonises WAPL to prevent premature loss of sister chromatid cohesion. Here the authors show that, despite a lack of sequence similarity, the Arabidopsis SWI1 protein functions as a novel Soronin-like WAPL antagonist ...
Chao Yang +6 more
doaj +2 more sources
Symmetric control of sister chromatid cohesion establishment. [PDF]
Nucleic Acids Res, 2023 Abstract Besides entrapping sister chromatids, cohesin drives other high-order chromosomal structural dynamics like looping, compartmentalization and condensation. ESCO2 acetylates a subset of cohesin so that cohesion must be established and only be established between nascent sister chromatids.
Zhang J +14 more
europepmc +3 more sources
Multivalent interaction of ESCO2 with the replication machinery is required for sister chromatid cohesion in vertebrates [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Jingrong Chen +2 more
exaly +2 more sources
The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks
Cells, 2021 The cohesin complex facilitates faithful chromosome segregation by pairing the sister chromatids after DNA replication until mitosis. In addition, cohesin contributes to proficient and error-free DNA replication.
Janne J. M. van Schie, Job de Lange
doaj +1 more source
Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei. [PDF]
PLoS Genetics, 2016 Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division.
T Niroshini Senaratne +3 more
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Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. [PDF]
PLoS Genetics, 2018 Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw breakage
Giuseppe Cortone +8 more
doaj +1 more source
S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit
mBio, 2022 During DNA replication, the newly created sister chromatids are held together until their separation at anaphase. The cohesin complex is in charge of creating and maintaining sister chromatid cohesion (SCC) in all eukaryotes.
Karan Choudhary +6 more
doaj +1 more source