Results 21 to 30 of about 921,868 (189)

Symmetric control of sister chromatid cohesion establishment. [PDF]

Nucleic Acids Res, 2023
Abstract Besides entrapping sister chromatids, cohesin drives other high-order chromosomal structural dynamics like looping, compartmentalization and condensation. ESCO2 acetylates a subset of cohesin so that cohesion must be established and only be established between nascent sister chromatids.
Zhang J, Li L, Miao Y, Liu X, Sun H, Jiang M, Li X, Li Z, Liu C, Liu B, Xu X, Cao Q, Hou W, Chen C, Lou H.   +14 more
europepmc   +3 more sources

Multivalent interaction of ESCO2 with the replication machinery is required for sister chromatid cohesion in vertebrates [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Jingrong Chen, Susannah Rankin
exaly   +2 more sources

Sister chromatid cohesion establishment during DNA replication termination. [PDF]

Science
Newly copied sister chromatids are tethered together by the cohesin complex, but how sister chromatid cohesion coordinates with DNA replication is poorly understood.
Cameron G, Gruszka DT, Gruar R, Xie S, Kaya Ç, Nasmyth KA, Baxter J, Srinivasan M, Yardimci H.   +8 more
europepmc   +8 more sources

Division of Labor between PCNA Loaders in DNA Replication and Sister Chromatid Cohesion Establishment

Molecular Cell, 2020
Celine Bouchoux, Frank Uhlmann
exaly   +2 more sources

Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion

Current Biology, 2022
Sofia Munoz, Chris W Seidel, Frank Uhlmann   +2 more
exaly   +2 more sources

The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks

Cells, 2021
The cohesin complex facilitates faithful chromosome segregation by pairing the sister chromatids after DNA replication until mitosis. In addition, cohesin contributes to proficient and error-free DNA replication.
Janne J. M. van Schie, Job de Lange
doaj   +1 more source

Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei. [PDF]

PLoS Genetics, 2016
Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division.
T Niroshini Senaratne, Eric F Joyce, Son C Nguyen, C-Ting Wu   +3 more
doaj   +1 more source

Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. [PDF]

PLoS Genetics, 2018
Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw breakage
Giuseppe Cortone, Ge Zheng, Pasquale Pensieri, Viviana Chiappetta, Rosarita Tatè, Eva Malacaria, Pietro Pichierri, Hongtao Yu, Francesca M Pisani   +8 more
doaj   +1 more source

S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit

mBio, 2022
During DNA replication, the newly created sister chromatids are held together until their separation at anaphase. The cohesin complex is in charge of creating and maintaining sister chromatid cohesion (SCC) in all eukaryotes.
Karan Choudhary, Ziv Itzkovich, Elisa Alonso-Perez, Hend Bishara, Barbara Dunn, Gavin Sherlock, Martin Kupiec   +6 more
doaj   +1 more source

Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

eLife, 2022
Cohesin organizes the genome by forming intra-chromosomal loops and inter-sister chromatid linkages. During gamete formation by meiosis, chromosomes are reshaped to support crossover recombination and two consecutive rounds of chromosome segregation ...
Rachael E Barton, Lucia F Massari, Daniel Robertson, Adèle L Marston   +3 more
doaj   +1 more source