A Physical Assay for Sister Chromatid Cohesion In Vitro [PDF]
Molecular Cell, 2007 Cohesion between sister chromatids depends on a multiprotein complex called cohesin that has been proposed to hold sister DNAs together by trapping them inside a large tripartite ring. Sister chromatid cohesion has hitherto only been detected by using cytological methods in living cells.
Ivanov, D, Nasmyth, K
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Calpain 2 is required for sister chromatid cohesion [PDF]
Chromosoma, 2010 Calpains form a family of Ca(2+)-dependent cysteine proteases involved in diverse cellular processes. However, the specific functions of each calpain isoform remain unknown. Recent reports have shown that calpain 2 (Capn2) is essential for cell viability. We have recently shown that Capn2 is a nuclear protease associated with chromosomes during mitosis
Magnaghi-Jaulin, Laura +5 more
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Sister chromatid cohesion establishment during DNA replication termination. [PDF]
ScienceNewly copied sister chromatids are tethered together by the cohesin complex, but how sister chromatid cohesion is coordinated with DNA replication is poorly understood.
Cameron G +8 more
europepmc +12 more sources
Symmetric control of sister chromatid cohesion establishment. [PDF]
Nucleic Acids Res, 2023 Abstract Besides entrapping sister chromatids, cohesin drives other high-order chromosomal structural dynamics like looping, compartmentalization and condensation. ESCO2 acetylates a subset of cohesin so that cohesion must be established and only be established between nascent sister chromatids.
Zhang J +14 more
europepmc +3 more sources
Multivalent interaction of ESCO2 with the replication machinery is required for sister chromatid cohesion in vertebrates [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Jingrong Chen +2 more
exaly +2 more sources
The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks
Cells, 2021 The cohesin complex facilitates faithful chromosome segregation by pairing the sister chromatids after DNA replication until mitosis. In addition, cohesin contributes to proficient and error-free DNA replication.
Janne J. M. van Schie, Job de Lange
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Replisome components in sister chromatid cohesion establishment [PDF]
, 2023 The chromosomal cohesin complex establishes sister chromatid cohesion during S phase, which forms the basis for the recognition of DNA replication products for their faithful segregation in mitosis. Here, I investigate the non-essential S.
Shrestha, Sudikchya
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Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. [PDF]
PLoS Genetics, 2018 Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw breakage
Giuseppe Cortone +8 more
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S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit
mBio, 2022 During DNA replication, the newly created sister chromatids are held together until their separation at anaphase. The cohesin complex is in charge of creating and maintaining sister chromatid cohesion (SCC) in all eukaryotes.
Karan Choudhary +6 more
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