Results 11 to 20 of about 10,437 (162)

Towards a Structural Mechanism for Sister Chromatid Cohesion Establishment at the Eukaryotic Replication Fork [PDF]

Biology, 2021
Cohesion between replicated chromosomes is essential for chromatin dynamics and equal segregation of duplicated genetic material. In the G1 phase, the ring-shaped cohesin complex is loaded onto duplex DNA, enriching at replication start sites, or ...
Sarah S. Henrikus, Alessandro Costa
doaj   +2 more sources

Chromatin assembly factor-1 preserves genome stability in ctf4∆ cells by promoting sister chromatid cohesion [PDF]

Cell Stress, 2023
Chromatin assembly and the establishment of sister chromatid cohesion are intimately connected to the progression of DNA replication forks. Here we examined the genetic interaction between the heterotrimeric chromatin assembly factor-1 (CAF-1), a central
Nagham Ghaddar, Pierre Luciano, Vincent Géli, Yves Corda   +3 more
doaj   +2 more sources

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion [PDF]

Nature Communications, 2020
WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
Janne J. M. van Schie, Atiq Faramarz, Jesper A. Balk, Grant S. Stewart, Erika Cantelli, Anneke B. Oostra, Martin A. Rooimans, Joanna L. Parish, Cynthia de Almeida Estéves, Katja Dumic, Ingeborg Barisic, Karin E. M. Diderich, Marjon A. van Slegtenhorst, Mohammad Mahtab, Francesca M. Pisani, Hein te Riele, Najim Ameziane, Rob M. F. Wolthuis, Job de Lange   +18 more
doaj   +2 more sources

Targeted sister chromatid cohesion by Sir2.

PLoS Genetics, 2011
The protein complex known as cohesin binds pericentric regions and other sites of eukaryotic genomes to mediate cohesion of sister chromatids. In budding yeast Saccharomyces cerevisiae, cohesin also binds silent chromatin, a repressive chromatin ...
Ching-Shyi Wu, Yu-Fan Chen, Marc R Gartenberg   +2 more
doaj   +3 more sources

Hsp90 Is Essential for Chl1-Mediated Chromosome Segregation and Sister Chromatid Cohesion [PDF]

mSphere, 2018
Recent studies have demonstrated that aberrant sister chromatid cohesion causes genomic instability and hence is responsible for the development of a tumor.
Nidhi Khurana, Sayan Bakshi, Wahida Tabassum, Mrinal K. Bhattacharyya, Sunanda Bhattacharyya   +4 more
doaj   +2 more sources

A non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres [PDF]

The EMBO Journal
The 16-subunit Constitutive Centromere-associated Network (CCAN)-based inner kinetochore is well-known for connecting centromeric chromatin to the spindle-binding outer kinetochore.
Lu Yan, Xueying Yuan, Mingjie Liu, Qinfu Chen, Miao Zhang, Junfen Xu, Ling-Hui Zeng, Long Zhang, Jun Huang, Weiguo Lu, Xiaojing He, Haiyan Yan, Fangwei Wang   +12 more
doaj   +2 more sources

S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion [PDF]

The EMBO Journal
Sororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1/2 is necessary for Sororin recruitment, it is by itself not sufficient.
Meiqian Jiang, Jiaxin Zhang, Jiankun He, Yu Miao, Linhui Wang, Haitao Zhong, Yingying Gong, Zhen Li, Li-Lin Du, Xingzhi Xu, Chunlai Chen, Alibek Ydyrys, Yisui Xia, Qinhong Cao, Huiqiang Lou, Wenya Hou   +15 more
doaj   +2 more sources

Sororin locks the DNA-exit gate of cohesin to preserve sister-chromatid cohesion [PDF]

Nature Communications
The cohesin complex mediates sister-chromatid cohesion by topologically entrapping DNA within an SMC1-SMC3-RAD21 ring, yet how Sororin preserves cohesion beyond its known role of antagonizing Pds5 binding to the release factor Wapl has remained unclear ...
Qinfu Chen, Xueying Yuan, Miao Shi, Xinyu Zhou, Shukai Zhu, Weiguo Lu, Haiyan Yan, Fangwei Wang   +7 more
doaj   +2 more sources

Interaction Between Rec8 and Mis4 Is Required for Axis-Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis. [PDF]

Genes Cells
We identified a Mis4 cohesin loader mutant that is specifically defective in chromatin axis formation and homologous recombination while retaining normal sister chromatid cohesion. The mis4‐LR mutant, carrying the L1150S and R1159G amino acid substitutions, exhibited reduced interaction between Mis4 and Rec8, suggesting a meiosis‐specific role for the ...
Sakuno T, Murayama Y, Haraguchi T, Hiraoka Y.   +3 more
europepmc   +2 more sources

Sister Chromatid Cohesion [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
During S phase, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle, and is thus an essential prerequisite for chromosome segregation.
Peters, J.-M. and Nishiyama, T.
  +7 more sources