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Sister Chromatid Cohesion [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 During S phase, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle, and is thus an essential prerequisite for chromosome segregation.
Peters, J.-M. and Nishiyama, T.
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Establishment of Sister Chromatid Cohesion [PDF]
Current Biology, 2009 The process of sister chromatid pairing, or cohesion establishment, is coupled to DNA replication and fundamental to proper chromosome segregation and cell viability. In the past year, several articles have provided important new insights into cohesion establishment, an activity predicated on the acetyltransferase Ctf7/Eco1. Here, I review new findings
Robert V. Skibbens, Skibbens, Robert V.
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Sister chromatid cohesion and recombination in meiosis [PDF]
Chromosoma, 2000 Sister chromatids are associated from their formation until their disjunction. Cohesion between sister chromatids is provided by protein complexes, of which some components are conserved across the kingdoms and between the mitotic and meiotic cell cycles.
van Heemst, D., Heyting, C.
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Sister Chromatid Cohesion Control and Aneuploidy [PDF]
Cytogenetic and Genome Research, 2011 Apart from a personal tragedy, could Down syndrome, cancer and infertility possibly have something in common? Are there links between a syndrome with physical and mental problems, a tumor growing out of control and the incapability to reproduce? These questions can be answered if we look at the biological functions of a protein complex, named cohesin ...
J.L. Barbero
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Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei. [PDF]
PLoS Genetics, 2016 Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division.
T Niroshini Senaratne +3 more
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Division of Labor between PCNA Loaders in DNA Replication and Sister Chromatid Cohesion Establishment [PDF]
Molecular Cell, 2020 Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister chromatids. Several replication-fork-associated "cohesion establishment factors," including the multifunctional Ctf18-RFC complex, aid ...
Celine Bouchoux, Frank Uhlmann
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Targeted sister chromatid cohesion by Sir2.
PLoS Genetics, 2011 The protein complex known as cohesin binds pericentric regions and other sites of eukaryotic genomes to mediate cohesion of sister chromatids. In budding yeast Saccharomyces cerevisiae, cohesin also binds silent chromatin, a repressive chromatin ...
Ching-Shyi Wu +2 more
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Cohesin: Functions beyond sister chromatid cohesion [PDF]
FEBS Letters, 2013 Faithful segregation of chromosomes during mitosis and meiosis is the cornerstone process of life. Cohesin, a multi‐protein complex conserved from yeast to human, plays a crucial role in this process by keeping the sister chromatids together from S‐phase to anaphase onset during mitosis and meiosis.
Mehta, Gunjan D. +3 more
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Analyzing Sister Chromatid Cohesion in Mammalian Cells [PDF]
, 2014 The metaphase chromosome spread technique and subsequent analysis of sister chromatid cohesion is used for (clinical) diagnosis of genetic abnormalities that can cause aberrant sister chromatid cohesion. In addition, the technique can be used to assess the contribution of novel genes to the cohesion establishment and maintenance pathways.
Katherine M, Feeney +2 more
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PHB2 Protects Sister-Chromatid Cohesion in Mitosis [PDF]
Current Biology, 2007 Cohesion between sister chromatids is essential for proper chromosome segregation in mitosis. In vertebrate mitotic cells, most cohesin is removed from the chromosome arms [1-4], but centromeric cohesin is protected by shugoshin until the onset of anaphase [5].
Takata, Hideaki +9 more
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