Results 151 to 160 of about 26,113 (251)

Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.

PLoS ONE, 2014
High fidelity chromosome segregation during mitosis requires that cells identify the products of DNA replication during S-phase and then maintain that identity until anaphase onset.
Kevin Tong, Robert V Skibbens
doaj   +1 more source

Key features of cohesin-binding genes and proposed roles for cohesin in genome-wide control of Pol II activity.

, 2013
Cohesin-binding genes (upper left) have higher levels of Pol II and promoter-proximal Pol II pausing than other active genes (lower left). Cohesin-binding genes are enriched for GAGA factor (GAF) binding upstream of the promoter and TG repeats in the ...
Ziva Misulovin (262237), Hojoong Kwak (392623), John T. Lis (7283), Cheri A. Schaaf (144616), Dale Dorsett (63431), Yanjiao Zhou (158268), David W. Gohara (361290), Audrey Watson (392625), Amanda Koenig (392624)   +8 more
core   +1 more source

Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]

, 2012
Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta, Leszek J. Tarnowski (160129), Milewski Michał, Michał Milewski (160136), Milewski, Michał, Plochocka, Danuta, Kurlandzka, Anna, Anna Kurlandzka, Marta Jurek, Kowalec, Piotr, Tarnowski, Leszek J, Jan Fronk, Jurek Marta, Piotr Kowalec, Tarnowski Leszek J., Danuta Plochocka, Jan Fronk (160145), Kowalec Piotr, Fronk Jan, Plochocka Danuta, Piotr Kowalec (160133), Fronk, Jan, Leszek J Tarnowski, Michał Milewski, Marta Jurek (160140), Kurlandzka Anna, Anna Kurlandzka (160147), Danuta Plochocka (160143)   +27 more
core   +1 more source

The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome

Clinical Epigenetics, 2017
Background Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIPBL loads cohesin onto chromatin.
Daniel A. Newkirk, Yen-Yun Chen, Richard Chien, Weihua Zeng, Jacob Biesinger, Ebony Flowers, Shimako Kawauchi, Rosaysela Santos, Anne L. Calof, Arthur D. Lander, Xiaohui Xie, Kyoko Yokomori   +11 more
doaj   +1 more source

Leukemogenic Activity of Cohesin Rings True.

, 2015
Cohesin complex components are frequently mutated in human myeloid cancers. Three new studies now show that cohesin mutations disrupt the differentiation of normal hematopoietic stem and progenitor cells and enhance self-renewal, shedding light on how ...
Somervaille, Tim C P, Williams, Mark S
core   +1 more source

Universal dynamics of cohesin-mediated loop extrusion

Most animal genomes are partitioned into Topologically Associating Domains (TADs), created by cohesin-mediated loop extrusion and defined by convergently oriented CTCF sites.
Tinevez, Jean-Yves, Robert, Marie-Cécile, Bertrand, Edouard, Zimmer, Christophe, Lelandais, Benoît, Sabaté, Thomas, Szalay, Michael   +6 more
core   +1 more source

Closing the loop on cohesin in hematopoiesis

Blood, 2019
In this issue of Blood, Sasca et al provide molecular insights into how dynamic changes in cohesin complex levels are critical to erythroid differentiation and how perturbations can contribute to myeloid malignancies.
openaire   +3 more sources

Different loading requirements of cohesin-STAG1 and cohesin-STAG2

, 2023
Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular.
openaire   +1 more source

Spo13 regulates cohesin cleavage

, 2002
A key aspect of meiotic chromosome segregation is that cohesin, the protein complex that holds sister chromatids together, dissociates from chromosome arms during meiosis I and from centromeric regions during meiosis II.
Brian H. Lee, Angelika Amon, Susanne Prinz   +2 more
core   +1 more source

Genetic basis of cohesinopathies

The Application of Clinical Genetics, 2013
José L Barbero Cellular and Molecular Biology Department, Biological Research Center, Madrid, Spain Abstract: Cohesin is a ring-form multifunctional protein complex, which was discovered during a search for molecules that keep sister chromatids ...
Barbero JL
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