Results 161 to 170 of about 14,462 (190)

A cohesin–RAD21 interactome

Biochemical Journal, 2012
The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation. In addition to its canonical function in chromosomal segregation, cohesin has been suggested by several lines of investigation in recent years to play additional roles in ...
Anil K, Panigrahi, Nenggang, Zhang, Subhendu K, Otta, Debananda, Pati   +3 more
openaire   +2 more sources

Cohesin in haematopoiesis and leukaemia

Current Opinion in Hematology, 2018
Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic ...
Roman, Galeev, Jonas, Larsson
openaire   +2 more sources

Genome folding by cohesin

Current Opinion in Genetics & Development
Chromosomes in eukaryotic cells undergo compaction at multiple levels and are folded into hierarchical structures to fit into the nucleus with limited dimensions. Three-dimensional genome organization needs to be coordinated with chromosome-templated processes, including DNA replication and gene transcription.
Shutao Qi, Zhubing Shi, Hongtao Yu
openaire   +2 more sources

Cohesin mutations in myeloid malignancies

Blood, 2021
Abstract Cohesin is a multisubunit protein complex that forms a ring-like structure around DNA. It is essential for sister chromatid cohesion, chromatin organization, transcriptional regulation, and DNA damage repair and plays a major role in dynamically shaping the genome architecture and maintaining DNA integrity.
Johann-Christoph Jann, Zuzana Tothova
openaire   +2 more sources

New insights into cohesin loading

Current Genetics, 2017
Cohesin is a conserved, ring-shaped protein complex that encircles sister chromatids and ensures correct chromosome segregation during mitosis and meiosis. It also plays a crucial role in the regulation of gene expression, DNA condensation, and DNA repair through both non-homologous end joining and homologous recombination.
Ireneusz, Litwin, Robert, Wysocki
openaire   +2 more sources

Releasin' Cohesin

Science's STKE, 2002
Cohesin attaches chromosomes to the mitotic spindle and allows separation of sister chromatids at anaphase. Phosphorylation of cohesin by a Polo-like kinase in yeast enhances cohesin degradation by separase at the onset of anaphase. However, in other eurkaryotes, the bulk of cohesin is removed from chromosomes earlier in mitosis (prophase ...
openaire   +2 more sources

Detection of Cohesin SUMOylation In Vivo

2016
Cohesin is a protein complex with key roles in chromosome biology, from chromatid segregation to DNA repair. Cohesin function is regulated by several posttranslational modifications, including phosphorylation, acetylation, ubiquitylation, and SUMOylation.
Marcelino, Bermúdez-López, Luis, Aragón   +1 more
openaire   +2 more sources

Cohesin and Cdk1: an anaphase barricade

Nature Cell Biology, 2010
Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
openaire   +3 more sources

Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism

Cell, 2021
Iain F Davidson, Daniel Canena, GORDANA Wütz   +2 more
exaly  

CTCF and R-loops are boundaries of cohesin-mediated DNA looping

Molecular Cell, 2023
Zhubing Shi, Edward J Banigan, Yoori Kim   +2 more
exaly