Three cohesin-PcG states and their interactions.
, 2013 In the PcG-silenced state (left), PRC1 (green rectangle) and PRC2 (tan rectangle) are both present, and the target genes are marked by the H3K27me3 histone modification made by PRC2.
Ziva Misulovin (262237) +6 more
core +1 more source
Myelodysplastic Syndromes: 2026 Update on Diagnosis, Risk‐Stratification and Management
American Journal of Hematology, Volume 101, Issue 9, Page 2393-2411, September 2026.ABSTRACT Disease Overview The myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). MDS occurs more frequently in older males and in individuals with prior exposure to cytotoxic therapy.
Guillermo Garcia‐Manero
wiley +1 more source
A new meiosis‐specific cohesin complex implicated in the cohesin code for homologous pairing
The EMBO Reports, 2011 We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21.
Ishiguro, Kei-ichiro +4 more
openaire +2 more sources
Cohesin's role in pluripotency and reprogramming. [PDF]
, 2015 Cohesin is required for ES cell self-renewal and iPS-mediated reprogramming of somatic cells. This may indicate a special role for cohesin in the regulation of pluripotency genes, perhaps by mediating long-range chromosomal interactions between gene ...
Lavagnolli, T +5 more
core +1 more source
Absolute quantification of cohesin, CTCF and their regulators in human cells
eLife, 2019 The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating cells,
Johann Holzmann +16 more
doaj +1 more source
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.
PLoS Genetics, 2018 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin +3 more
doaj +1 more source
A splicing factor-cohesin association links RNA processing to cohesin-dependent genome folding
Cell ReportsSummary: Interphase cohesin organizes the genome into loops and domains, yet how cohesin is efficiently recruited and loaded onto chromatin in cells remains incompletely understood.
Tao Wu +9 more
doaj +1 more source
Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes [PDF]
, 2000 A multisubunit protein complex, termed cohesin. plays an essential role in sister chromatid cohesion in yeast and in Xenopus laevis cell-free extracts. We report here that two distinct cohesin complexes exist in Xenopus egg extracts.
Kobayashi, R. +3 more
core +1 more source
Taking cohesin and condensin in context
PLOS Genetics, 2018 Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome.
Kobe C. Yuen, Jennifer L. Gerton
openaire +3 more sources
Regulation of cohesin cleavage during meiosis in Saccharomyces cerevisiae [PDF]
, 2017 Meiosis is a specialized form of cell division where homologous chromosomes are segregated in meiosis I before sister chromatids are segregated in meiosis II.
Galander, Stefan
core