Results 81 to 90 of about 26,113 (251)

Liberating cohesin from cohesion [PDF]

, 2017
Cohesin was identified through its major role in holding sister chromatids together. We are learning through analysis of cohesin and other members of the protein family (SMC [structural maintenance of chromosomes]) and their regulators that these ring ...
Bloom, K.
core   +2 more sources

Genomic analysis of cohesin dynamics in fission yeast [PDF]

, 2009
Cohesin holds sister chromatids together and facilitates their accurate segregation in mitosis. Little is known about how and where cohesin binds to chromosomes.
Schmidt, C.K., Schmidt, C K
core  

Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]

, 2015
SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Soh, Young-Min, Stephan Gruber, Kim, Cheolhee, Kim, Y.-G., Kim, YG, Oh, B., Bürmann, F., Soh, Y., Shin, H.-C., Oh, Byung-Ha, Shin, HC, Lee, H., Durand-Diebold, M., Jin, KS, S. Gruber, Lee, Hansol, Kim, Ho Min, Shin, Ho-Chul, Kim, HM, Buermann, Frank, Toseland, C., Kim, H.M., Oda, T, Soh, YM, Durand-Diebold, Marie-Laure, -Diebold, ML, Kim, Y., Gruber, S., Jin, Kyeong Sik, Bürmann, Frank, Oh, BH, Durand-Diebold, M.-L., Kim, Yeon-Gil, Kong, Min-Seok, Kim, C, Oda, Takashi, C. Kim, Lee, Nam Ki, M-L Durand-Diebold, Lee, N.K., Kim, H., Kim, Soo Jin, Sato, M., Gruber, S, Toseland, Christopher P., Oda, T., Lee, NK, M-S Kong, Diebold-Durand, Marie-Laure, Lee, N., Y.-G. Kim, Kim, C., Toseland, C.P., Soh, Young Min, Kim, Ho-Min, Gruber, Stephan, Soh, Y.-M., Oh, B.-H., Sato, Mamoru, Buermann, F., Kim, S., Jin, K.S., Shin, H., Kim, S.J., Kong, M.-S., Kong, M., S. J. Kim, Burmann, F, Jin, K., C. P. Toseland   +69 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The specific roles of cohesin-SA1 and cohesin-SA2 in gene regulation and genome organization [PDF]

, 2018
Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura:13-07-2018The use of Chromosome Conformation Capture (3C)-derived techniques for probing 3D genome structure ...
Kojic, Aleksandar
core   +1 more source

Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function

Epigenetics & Chromatin
Background The evolutionarily conserved cohesin complex is a pleiotropic regulator of chromosome structure and function, participating in sister chromatid cohesion, transcriptional regulation of genes, DNA replication, and DNA repair.
Natalie L. Rittenhouse, Riya Gohil, June E. Arricastres, Jill M. Dowen   +3 more
doaj   +1 more source

Of Rings and Rods: Regulating Cohesin Entrapment of DNA to Generate Intra- and Intermolecular Tethers.

PLoS Genetics, 2016
The clinical relevance of cohesin in DNA repair, tumorigenesis, and severe birth defects continues to fuel efforts in understanding cohesin structure, regulation, and enzymology.
Robert V Skibbens
doaj   +1 more source

Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. [PDF]

PLoS Genetics, 2016
The cohesin protein complex mediates sister chromatid cohesion and participates in transcriptional control of genes that regulate growth and development.
Amanda Swain, Ziva Misulovin, Michelle Pherson, Maria Gause, Kathie Mihindukulasuriya, Ryan A Rickels, Ali Shilatifard, Dale Dorsett   +7 more
doaj   +1 more source

Developing a peptide to disrupt cohesin head domain interactions

iScience, 2023
Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias, Samar Gani, Yana Lerner, Katreen Yamin, Chen Tor, Adarsh Patel, Avi Matityahu, Moshe Dessau, Nir Qvit, Itay Onn   +9 more
doaj   +1 more source

Cohesin codes – interpreting chromatin architecture and the many facets of cohesin function [PDF]

Journal of Cell Science, 2013
Summary Sister chromatid tethering is maintained by cohesin complexes that minimally contain Smc1, Smc3, Mcd1 and Scc3. During S-phase, chromatin-associated cohesins are modified by the Eco1/Ctf7 family of acetyltransferases. Eco1 proteins function during S phase in the context of replicated sister chromatids to convert chromatin-bound ...
Soumya, Rudra, Robert V, Skibbens
openaire   +2 more sources