Results 81 to 90 of about 18,597 (218)

Homologous recombination, sister chromatid cohesion, and chromosome condensation in mammalian meiosis [PDF]

, 2002
In the life cycle of sexually reproducing eukaryotes, haploid and diploid generations of cells alternate. Two types of cell division occur in such a life cycle: mitosis and meiosis. They are compared in chapter 1 .
Eijpe, M.
core  

Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair [PDF]

, 2014
Cohesin is an essential multiprotein complex that mediates sister chromatid cohesion critical for proper segregation of chromosomes during cell division. Cohesin is also involved in DNA double-strand break (DSB) repair.
Pham, Hoang Xuan, Chen, Hsiao-Yuan, Schmiesing, John A, Zeng, Weihua, Berns, Michael, Kim, Jong-Soo, Kong, Xiangduo, Ball, Alexander R, Yokomori, Kyoko   +8 more
core   +1 more source

Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP binding

Nature Communications, 2023
The ring-shaped cohesin complex is a key player in sister chromatid cohesion, DNA repair, and gene transcription. The loading of cohesin to chromosomes requires the loader Scc2 and is regulated by ATP.
Aditi Kaushik, Thane Than, Naomi J. Petela, Menelaos Voulgaris, Charlotte Percival, Peter Daniels, John B. Rafferty, Kim A. Nasmyth, Bin Hu   +8 more
doaj   +1 more source

Impact of Methylparaben on Cumulus Cell DNA Integrity and Porcine Oocyte Developmental Competence In Vitro

Journal of Applied Toxicology, EarlyView.
ABSTRACT Parabens (PBs) are compounds widely used as preservatives in personal care products, food, and pharmaceuticals. Methylparaben (MePB) is the most used by different industries due to its chemical properties and low cost. The high daily human exposure to these compounds has raised concerns about their potential effects on health, particularly on ...
Yenny Ramírez‐Jara, Brenda Casado, Miguel Betancourt, Adyeni Barajas‐Salinas, Eduardo Casas, Gabriela Hurtado‐Alvarado, Juan José Rodríguez‐Mercado, Alma López, Iván Bahena, Lizbeth Juárez‐Rojas, Leticia González‐Núñez, Fahiel Casillas   +11 more
wiley   +1 more source

Regulation of cohesin cleavage during meiosis in Saccharomyces cerevisiae [PDF]

, 2017
Meiosis is a specialized form of cell division where homologous chromosomes are segregated in meiosis I before sister chromatids are segregated in meiosis II.
Galander, Stefan
core  

Cohesin-mediated interactions organize chromosomal domain architecture [PDF]

, 2013
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information.
Georgopoulou, Dimitra, Hadjur, Suzana, Vietri Rudan, Matteo, Schroth, Gary P, Sofueva, Sevil, Chan, Wen-Ching, Pollard, Steven M, Tanay, Amos, Mira-Bontenbal, Hegias, Yaffe, Eitan   +9 more
core   +1 more source

Cohesin positions the epigenetic reader Phf2 within the genome

The EMBO Journal
Genomic DNA is assembled into chromatin by histones, and extruded into loops by cohesin. These mechanisms control important genomic functions, but whether histones and cohesin cooperate in genome regulation is poorly understood.
Wen Tang, Lorenzo Costantino, Roman Stocsits, Gordana Wutz, Rene Ladurner, Otto Hudecz, Karl Mechtler, Jan-Michael Peters   +7 more
doaj   +1 more source

A multi-step pathway for the establishment of sister chromatid cohesion.

PLoS Genetics, 2007
The cohesion of sister chromatids is mediated by cohesin, a protein complex containing members of the structural maintenance of chromosome (Smc) family. How cohesins tether sister chromatids is not yet understood.
Mark Milutinovich, Elçin Unal, Chris Ward, Robert V Skibbens, Douglas Koshland   +4 more
doaj   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Cohesin: its roles and mechanisms. [PDF]

, 2009
The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control.
Nasmyth, Kim, Haering, CH
core   +1 more source