Results 51 to 60 of about 18,597 (218)

A microscopic study of cohesin [PDF]

, 2017
Cohesin is a ring-shaped Smc (Structural Maintenance of Chromosomes) complex that mediates DNA-DNA interactions between chromosomes (sister chromatid cohesion) and within chromosomes (looping).
Rhodes, James, James Rhodes
core   +2 more sources

Developing a peptide to disrupt cohesin head domain interactions

iScience, 2023
Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias, Samar Gani, Yana Lerner, Katreen Yamin, Chen Tor, Adarsh Patel, Avi Matityahu, Moshe Dessau, Nir Qvit, Itay Onn   +9 more
doaj   +1 more source

Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. [PDF]

PLoS Genetics, 2016
The cohesin protein complex mediates sister chromatid cohesion and participates in transcriptional control of genes that regulate growth and development.
Amanda Swain, Ziva Misulovin, Michelle Pherson, Maria Gause, Kathie Mihindukulasuriya, Ryan A Rickels, Ali Shilatifard, Dale Dorsett   +7 more
doaj   +1 more source

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies. [PDF]

, 2019
Cohesin complex disruption alters gene expression, and cohesin mutations are common in myeloid neoplasia, suggesting a critical role in hematopoiesis.
Green, Anthony R., Osborne, Cameron S., Evan, Theo, Papaemmanuil, Elli, Szybinski, Jakub, Russell, Nigel, Göttgens, Berthold, Huntly, Brian J.P., Yun, Haiyang, Gallipoli, Paolo, Giotopoulos, George, Wilson, Nicola K., Campbell, Peter, Hills, Robert, Sasca, Daniel, Gerstung, Moritz   +15 more
core   +2 more sources

Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function

Epigenetics & Chromatin
Background The evolutionarily conserved cohesin complex is a pleiotropic regulator of chromosome structure and function, participating in sister chromatid cohesion, transcriptional regulation of genes, DNA replication, and DNA repair.
Natalie L. Rittenhouse, Riya Gohil, June E. Arricastres, Jill M. Dowen   +3 more
doaj   +1 more source

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

PLoS Biology, 2005
Cohesin is a protein complex that is required to hold sister chromatids together. Cleavage of the Scc1 subunit of cohesin by the protease separase releases the complex from chromosomes and thereby enables the separation of sister chromatids in anaphase ...
Silke Hauf, Elisabeth Roitinger, Birgit Koch, Christina M Dittrich, Karl Mechtler, Jan-Michael Peters   +5 more
doaj   +1 more source

STAG2 promotes the myelination transcriptional program in oligodendrocytes

eLife, 2022
Cohesin folds chromosomes via DNA loop extrusion. Cohesin-mediated chromosome loops regulate transcription by shaping long-range enhancer–promoter interactions, among other mechanisms.
Ningyan Cheng, Guanchen Li, Mohammed Kanchwala, Bret M Evers, Chao Xing, Hongtao Yu   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Enigmatic Ladies of the Rings: How Cohesin Dysfunction Affects Myeloid Neoplasms Insurgence

Frontiers in Cell and Developmental Biology, 2019
The genes of the cohesin complex exert different functions, ranging from the adhesion of sister chromatids during the cell cycle, DNA repair, gene expression and chromatin architecture remodeling.
Alex Pezzotta, Mara Mazzola, Marco Spreafico, Anna Marozzi, Anna Pistocchi   +4 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source