Results 51 to 60 of about 26,113 (251)
CTCF and R-loops are boundaries of cohesin-mediated DNA looping
bioRxiv, 2022 Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional (3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a polar orientation.
Hong-Shan Zhang +6 more
semanticscholar +1 more source
Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin
Cell Reports, 2016 Cohesin is essential for the hierarchical organization of the eukaryotic genome and plays key roles in many aspects of chromosome biology. The conformation of cohesin bound to DNA remains poorly defined, leaving crucial gaps in our understanding of how ...
Johannes Stigler +3 more
doaj +1 more source
Epigenetics & Chromatin, 2021 Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions through the process
Arkadiy K. Golov +3 more
doaj +1 more source
iScience, 2023 Summary: Chromatin organization, whose malfunction causes various diseases including cancer, is fundamentally controlled by cohesin. While cancer cells have been found with mutated or misexpressed cohesin genes, there is no comprehensive survey about the
Jiankang Wang, Ryuichiro Nakato
doaj +1 more source
Bridging-induced phase separation induced by cohesin SMC protein complexes
Science Advances, 2021 Yeast cohesin complexes cluster onto long DNA into liquid droplets, which they accomplish by ATP-independent DNA bridging. Structural maintenance of chromosome (SMC) protein complexes are able to extrude DNA loops.
Je-Kyung Ryu +11 more
semanticscholar +1 more source
Chromatin insulators and cohesins [PDF]
The EMBO Reports, 2008 Chromatin insulators have evolved to regulate transcription by using regulatory elements that are often distant from each other on the linear genome. This feature is position‐dependent—that is, a functional insulator must be positioned between the enhancer and its target promoter (Wallace & Felsenfeld, 2007).
Anita, Göndör, Rolf, Ohlsson
openaire +2 more sources
Cohesin-mediated interactions organize chromosomal domain architecture [PDF]
, 2013 To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information.
Georgopoulou, Dimitra +9 more
core +1 more source
Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.
PLoS Genetics, 2013 Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during ...
Yuri M Moshkin +9 more
doaj +1 more source
Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
Frontiers in Oncology, 2021 The occurrence of gene mutation is a major contributor to the initiation and propagation of acute myeloid leukemia (AML). Accumulating evidence suggests that genes encoding cohesin subunits have a high prevalence of mutations in AML, especially in the t ...
Caixia Han +6 more
doaj +1 more source
Cohesin regulates alternative splicing
Science Advances, 2023 Cohesin, a trimeric complex that establishes sister chromatid cohesion, has additional roles in chromatin organization and transcription. We report that among those roles is the regulation of alternative splicing through direct interactions and in situ ...
Amit K Singh +4 more
semanticscholar +1 more source