Results 11 to 20 of about 19,982 (216)
Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2. [PDF]
Nature Communications, 2023 Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading is unclear.
Alonso-Gil, Dácil +4 more
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Pds5 promotes cohesin acetylation and stable cohesin–chromosome interaction [PDF]
The EMBO Reports, 2012 International audiencePds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1.
Javerzat, Jean-Paul +12 more
core +5 more sources
Cohesin loading and sliding [PDF]
Journal of Cell Science, 2011 Cohesin is best known as a crucial component of chromosomal stability. Composed of several essential subunits in budding yeast, cohesin forms a ring-like complex that is thought to embrace sister chromatids, thereby physically linking them until their ...
Maria T. Ocampo-Hafalla, Frank Uhlmann
core +3 more sources
Cohesin and chromosome segregation [PDF]
Current Biology, 2018 Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is established between ...
Makrantoni, Vasso, Marston, Adele L
core +4 more sources
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML [PDF]
JCI Insight, 2021 The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myeloid ...
Zuzana Tothova +22 more
doaj +2 more sources
PLoS Genetics, 2015 The Structural Maintenance of Chromosome (SMC) complex, termed cohesin, is essential for sister chromatid cohesion. Cohesin is also important for chromosome condensation, DNA repair, and gene expression. Cohesin is comprised of Scc3, Mcd1, Smc1, and Smc3.
Ola Orgil +5 more
doaj +2 more sources
Biochemical Journal, 2012 The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation.
Nenggang Zhang +3 more
core +3 more sources
Cohesin residency determines chromatin loop patterns [PDF]
eLife, 2020 The organization of chromatin into higher order structures is essential for chromosome segregation, the repair of DNA-damage, and the regulation of gene expression.
Lorenzo Costantino +4 more
doaj +2 more sources
The multifaceted roles of cohesin in cancer
Journal of Experimental & Clinical Cancer Research, 2022 The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and ...
Maria M. Pallotta +5 more
core +4 more sources
A minimal cellulosome-like system in Cellulosilyticum lentocellum. [PDF]
FEBS Open BioCellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
Allan J, Alstrom-Moore A, Black GW.
europepmc +2 more sources