Results 11 to 20 of about 18,597 (218)
Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2 [PDF]
Nature Communications, 2022 Abstract Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates cohesin’s ATPase and is essential for loop extrusion, but its requirement for cohesin loading is currently unclear. Here we have examined the effect of reducing NIPBL levels on the behavior of the two cohesin variants carrying STAG1 or STAG2 ...
Dácil Alonso Gil +4 more
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Pds5 promotes cohesin acetylation and stable cohesin–chromosome interaction [PDF]
The EMBO Reports, 2012 Pds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1. However, Pds5 is also required to maintain sister-chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a
Vaur, Sabine +4 more
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Cohesin and chromosome segregation [PDF]
Current Biology, 2018 Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is established between the two newly duplicated sister chromatids during S phase.
Makrantoni, Vasso, Marston, Adele L
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Cohesin loading and sliding [PDF]
Journal of Cell Science, 2011 Cohesin is best known as a crucial component of chromosomal stability. Composed of several essential subunits in budding yeast, cohesin forms a ring-like complex that is thought to embrace sister chromatids, thereby physically linking them until their timely segregation during cell division.
Maria T, Ocampo-Hafalla, Frank, Uhlmann
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Mechanical disengagement of the cohesin ring [PDF]
Nature Structural & Molecular Biology, 2023 AbstractCohesin forms a proteinaceous ring that is thought to link sister chromatids by entrapping DNA and counteracting the forces generated by the mitotic spindle. Whether individual cohesins encircle both sister DNAs and how cohesin opposes spindle-generated forces remains unknown.
Martina Richeldi +5 more
core +7 more sources
A cohesin–RAD21 interactome [PDF]
Biochemical Journal, 2012 The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation. In addition to its canonical function in chromosomal segregation, cohesin has been suggested by several lines of investigation in recent years to play additional roles in ...
Anil K, Panigrahi +3 more
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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML [PDF]
JCI Insight, 2021 The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myeloid ...
Zuzana Tothova +22 more
doaj +2 more sources
A conserved domain in the scc3 subunit of cohesin mediates the interaction with both mcd1 and the cohesin loader complex. [PDF]
PLoS Genetics, 2015 The Structural Maintenance of Chromosome (SMC) complex, termed cohesin, is essential for sister chromatid cohesion. Cohesin is also important for chromosome condensation, DNA repair, and gene expression. Cohesin is comprised of Scc3, Mcd1, Smc1, and Smc3.
Ola Orgil +5 more
doaj +2 more sources
Cohesin-Mediated Chromatin Interactions and Autoimmunity [PDF]
Frontiers in Immunology, 2022 Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-
Venkataragavan Chandrasekaran +12 more
doaj +3 more sources
Cohesin in haematopoiesis and leukaemia [PDF]
Current Opinion in Hematology, 2018 Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic ...
Roman, Galeev, Jonas, Larsson
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