Results 11 to 20 of about 26,113 (251)
Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2 [PDF]
Nature Communications, 2022 NIPBL is considered the cohesin loader. Here, the authors report that a drastic reduction of NIPBL levels reduces chromatin-bound cohesin-STAG2 genome wide while cohesin-STAG1 increases and can still be found at CTCF-bound sites but cannot form loops ...
Dácil Alonso-Gil +4 more
semanticscholar +6 more sources
Cohesin architecture and clustering in vivo [PDF]
eLife, 2021 Cohesin helps mediate sister chromatid cohesion, chromosome condensation, DNA repair, and transcription regulation. We exploited proximity-dependent labeling to define the in vivo interactions of cohesin domains with DNA or with other cohesin domains ...
Siheng Xiang, Douglas Koshland
doaj +2 more sources
Cohesin and chromosome segregation [PDF]
Current Biology, 2018 Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is established between the two newly duplicated sister chromatids during S phase.
Makrantoni, Vasso, Marston, Adele L
openaire +4 more sources
Genome-wide control of RNA polymerase II activity by cohesin.
PLoS Genetics, 2013 Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest ...
Cheri A Schaaf +8 more
doaj +2 more sources
PLoS Genetics, 2015 The Structural Maintenance of Chromosome (SMC) complex, termed cohesin, is essential for sister chromatid cohesion. Cohesin is also important for chromosome condensation, DNA repair, and gene expression. Cohesin is comprised of Scc3, Mcd1, Smc1, and Smc3.
Ola Orgil +5 more
doaj +2 more sources
The structural basis for cohesin-CTCF anchored loops
Nature, 2020 Cohesin catalyses the folding of the genome into loops that are anchored by CTCF1. The molecular mechanism of how cohesin and CTCF structure the 3D genome has remained unclear. Here we show that a segment within the CTCF N terminus interacts with the SA2–
Yan Li +10 more
semanticscholar +5 more sources
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML [PDF]
JCI Insight, 2021 The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myeloid ...
Zuzana Tothova +22 more
doaj +2 more sources
PLoS ONE, 2014 The immunoglobulin heavy chain locus (Igh) features higher-order chromosomal interactions to facilitate stage-specific assembly of the Ig molecule.
Gamze Günal-Sadık +5 more
doaj +2 more sources
Cohesin loading and sliding [PDF]
Journal of Cell Science, 2011 Cohesin is best known as a crucial component of chromosomal stability. Composed of several essential subunits in budding yeast, cohesin forms a ring-like complex that is thought to embrace sister chromatids, thereby physically linking them until their timely segregation during cell division.
Maria T, Ocampo-Hafalla, Frank, Uhlmann
openaire +3 more sources
Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters [PDF]
Nature Communications, 2022 Innate immune responses rely on inducible gene expression programmes which, in contrast to steady-state transcription, are highly dependent on cohesin. Here we address transcriptional parameters underlying this cohesin-dependence by single-molecule RNA ...
Irene Robles-Rebollo +15 more
semanticscholar +3 more sources