Results 111 to 120 of about 100,632 (325)

Wireless Bioelectronic Modulation of Membrane Potential in Glioblastoma Using Carbon Nanotube Porins

Advanced Science, EarlyView.
A schematic illustrating glioblastoma cell membrane modulation using carbon nanotube porins (CNTPs) and an applied voltage. CNTPs enable ion flux leading to changes in membrane potential. This figure summarizes the concept of bioelectronic control of cell membrane voltage.
Fleur Groualle, David Onion, Julie A. Watts, Graham A. Rance, Aleksandr Noy, Beth Coyle, Frankie J. Rawson   +6 more
wiley   +1 more source

Manifested U‐Waves Prior to Seizure Attacks in a Patient Who Had Remote Subarachnoid Hemorrhage: A Case Report

Annals of Noninvasive Electrocardiology
Sudden unexpected death in epilepsy (SUDEP) refers to unpredictable demise of a person following a seizure. Electroencephalograms can directly measure electrical activity in the brain; however, it cannot predict when seizures will occur.
Nao Kaneko, Masao Watanabe, Shusuke Mori, Isik Turker, Ken Okamoto, Takao Urabe, Tomohiko Ai   +6 more
doaj   +1 more source

The effect of repolarization duration on the indices of the pump function of the heart ventricles in animals with different types of activation of the myocardium under ectopic excitation of ventricles

Russian Open Medical Journal, 2018
Background — The aim of the work was to study the influence of myocardial repolarization on the indices of the pump function in animals with different types of the myocardial activation (dog, amphibians) under ectopic excitation of the ventricles ...
Natalya A. Kibler, Vladimir P. Nyzhny, Dmitry N. Shmakov   +2 more
doaj   +1 more source

Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization

Nature Communications, 2015
High-frequency action potential (AP) transmission is essential for rapid information processing in the central nervous system. Voltage-dependent Kv3 channels play an important role in this process thanks to their high activation threshold and fast ...
A. Labro, M. Priest, Jérôme J. Lacroix, D. Snyders, F. Bezanilla   +4 more
semanticscholar   +1 more source

Aging of poled ferroelectric ceramics due to relaxation of random depolarization fields by space-charge accumulation near grain boundaries

, 2009
Migration of charged point defects triggered by the local random depolarization field is shown to plausibly explain aging of poled ferroelectric ceramics providing reasonable time and acceptor concentration dependences of the emerging internal bias field.
D. M. Smyth, G. Arlt, H. Kungl, H. Thomann, J. Glaum, K. Carl, K. Okazaki, K. Okazaki, K. Okazaki, L. D. Landau, M. J. Hoffmann, O. Hirsch, S. Takahashi, T. Granzow, Yu. A. Genenko   +14 more
core   +1 more source

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source

The Effects of Pediatric Acute Lymphoblastic Leukemia Treatment on Cardiac Repolarization

Children
Background: In recent years, cardiac dysfunction in childhood cancer survivors has become an important issue. Studies are focusing on identifying means for the early identification of patients at risk.
Diana R. Lazar, Simona Cainap, Florin Leontin Lazar, Dana Maniu, Cristina Blag, Madalina Bota, Marius C. Colceriu, Mihnea Zdrenghea   +7 more
doaj   +1 more source

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, EarlyView.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization

Journal of the Royal Society Interface, 2014
Impulse propagation in biological tissues is known to be modulated by structural heterogeneity. In cardiac muscle, improved understanding on how this heterogeneity influences electrical spread is key to advancing our interpretation of dispersion of ...
A. Bueno-Orovio, D. Kay, V. Grau, B. Rodríguez, K. Burrage   +4 more
semanticscholar   +1 more source

Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K [PDF]

, 2018
SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric Gi proteins in many cell types, including cardiomyocytes.
Al-Owais, Moza, Cheng, Lan, Covarrubias, Manuel, Koch, Walter J., Manning, David R., Peers, Chris, Riobo-Del Galdo, Natalia A   +6 more
core   +1 more source