Results 171 to 180 of about 41,808 (246)

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim   +6 more
wiley   +1 more source

Contemporary Perspectives on J-Wave Syndromes: An Expert Consensus Statement. [PDF]

open access: yesJ Arrhythm
Nademanee K   +22 more
europepmc   +1 more source

The sympathoregulatory region of the mouse rostral brainstem relies on both GABA and glycine to generate inhibitory currents

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Our study demonstrates that both GABA and glycine mediate inhibitory postsynaptic currents in the ventrolateral/ventromedial medulla (VLM/VMM) and increasing the activity of inhibitory synapses facilitates glycine release. We found that presympathetic VLM/VMM neurons receive glycinergic inputs, which release both glycine and GABA,
Hong Gao   +5 more
wiley   +1 more source

Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity. [PDF]

open access: yesCell Res
Li Y   +33 more
europepmc   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque   +5 more
wiley   +1 more source

Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Impact of Omecamtiv Mecarbil (OM) on in‐silico models of heart failure. A mathematical electromechanical model of human ventricular tissue is used to simulate the effects of OM in heart failure with reduced ejection fraction (HFrEF).
Maria Teresa Mora   +8 more
wiley   +1 more source

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