Results 171 to 180 of about 66,487 (305)

Performing Euroscepticism: the UK press and Cameron’s Bloomberg speech [PDF]

, 2015
A Menon, B Hawkins, Belfast Telegraph, C Gifford, C Gifford, C Leconte, C Pentland, D Cameron, D Hannan, F Serricchio, G Wilkes, J Díez Medrano, J FitzGibbon, K Donaldson, K Oppermann, L Price, M Bruter, M Spiering, O Daddow, O Daddow, P Anderson, P Gannon, P Sherrington, P Taggart, R Brookes, R Ford, R Harmsen, R Liddle, S Usherwood, S Vasilopoulou, W Wallace   +30 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The variability in pattern, presentation, and outcomes in the management of congenital corrected transposition of the great artery (ccTGA): A Systematic Review and Meta-analysis. [PDF]

Niger Med J
Chinawa JM, Chinawa T AT, Uwaezuoke NA, Igoche PD.   +3 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Retrospective Media Content Analysis of Suicide Reporting in Nigerian Print Media. [PDF]

Cureus
Okpalauwaekwe U, Enwerem KE, Audu M, Mela M.   +3 more
europepmc   +1 more source

ReportAGE: Automatically extracting the exact age of Twitter users based on self-reports in tweets. [PDF]

PLoS One, 2022
Klein AZ, Magge A, Gonzalez-Hernandez G.
europepmc   +1 more source

Towards an Unsupervised Speaking Style Voice Building Framework:Multi-Style Speaker Diarization [PDF]

, 2012
Barra-Chicote, R, Ferreiros, J, Lopez-Ludena, V, Lorenzo, J, Martinez, B, Montero, J M, Yamagishi, J   +6 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Oculogyric crisis in two patients treated with aripiprazole for chronic tics. [PDF]

Neurol Sci
Cavanna AE, Colangelo C, Melina C, Ravasi A, Arienti G, Riva A, Nacinovich R, Seri S.   +7 more
europepmc   +1 more source