Results 101 to 110 of about 4,208,353 (305)
Humaniora, 2013 Learning means changing. Conditions of learning rely on a person's organizational thought against the learning process. One’s organizational thought is categorized into three major categories, each of which is divided into two phases: pre-conventional ...
Esther Christiana +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cranial hypertrophic pachymeningitis with myelodysplastic syndrome
HeliyonHypertrophic pachymeningitis (HP) is a rare inflammatory disease characterized by thickening of the dura mater. HP develops with several inflammatory diseases.
Shohei Kikuchi +9 more
doaj +1 more source
Acceleration by Strong Interactions
, 2017 Beyond the attractive strong potential needed for hadronic bound states, strong interactions are predicted to provide repulsive forces depending on the color charges involved.
Erdmann, Martin +2 more
core
, 2016 In this paper we consider the fact that the simple criterion used to label fast radio transient events as either fast radio bursts (FRBs, thought to be extragalactic with as yet unknown progenitors) or rotating radio transients (RRATs, thought to be ...
Keane, E. F.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
First report of kleptoparasitism in Leptodeira rhombifera (Squamata, Dipsadidae) for a yellow toad Incilius luetkenii (Anura, Bufonidae) in Nicaragua [PDF]
Travaux du Muséum National d’Histoire Naturelle “Grigore Antipa”Kleptoparasitism is a widely observed feeding strategy across various animal taxa. In snakes it is well documented in captivity, but rarely reported in the wild. This observation is the first of its kind in Nicaragua.
Milton Salazar-Saavedra +1 more
doaj +3 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Detecting Switching Strategies in Equity Hedge Funds [PDF]
Equity hedge funds are thought to effectively operate market timing by implementing switching strategies conditional on market circumstances. In this paper we use only the reported monthly returns on a set of funds to infer the type of switching ...
Anca Dimitriu, Carol Alexander
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source