Results 21 to 30 of about 357,104 (247)
Covalent 18F-Radiotracers for SNAPTag: A New Toolbox for Reporter Gene Imaging
Pharmaceuticals, 2021 There is a need for versatile in vivo nuclear imaging reporter systems to foster preclinical and clinical research. We explore the applicability of the SNAPTag and novel radiolabeled small-molecule ligands as a versatile reporter gene system for in vivo ...
Sophie Stotz +4 more
doaj +1 more source
, 2009 Reporter gene assays are versatile and sensitive methods of assaying numerous targets in high-throughput drug-screening programs. A variety of reporter genes allow users a choice of signal that can be tailored to the required sensitivity, the available detection apparatus, the cellular system employed, and the required compatibility with multiplexed ...
Liu, A.M.F. +3 more
openaire +3 more sources
Adenovirus-mediated gene transfer in primary murine adipocytes
Journal of Lipid Research, 2000 The transfer of genes into primary murine adipocytes using an adenovirus system has been developed. A recombinant adenovirus was constructed (expressing green fluorescent protein [GFP] under the control of the strong cytomegalovirus [CMV] promoter and a ...
Ann Vogel Hertzel +2 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2013 Despite the development of potent siRNAs that effectively target genes responsible for skin disorders, translation to the clinic has been hampered by inefficient delivery through the stratum corneum barrier and into the live cells of the epidermis ...
Robyn P Hickerson +9 more
doaj +1 more source
Environmental Application of Reporter-Genes Based Biosensors for Chemical Contamination Screening
Archives of Environmental Protection, 2014 The paper presents results of research concerning possibilities of applications of reporter-genes based microorganisms, including the selective presentation of defects and advantages of different new scientific achievements of methodical solutions in ...
Matejczyk Marzena +1 more
doaj +1 more source
GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives
Stem Cell Reports, 2016 The ability to reliably express fluorescent reporters or other genes of interest is important for using human pluripotent stem cells (hPSCs) as a platform for investigating cell fates and gene function.
Tim Kao +24 more
doaj +1 more source
Abnormal dosage compensation of reporter genes driven by the Drosophila glass multiple reporter (GMR) enhancer-promoter. [PDF]
PLoS ONE, 2011 In Drosophila melanogaster the male specific lethal (MSL) complex is required for upregulation of expression of most X-linked genes in males, thereby achieving X chromosome dosage compensation.
Corey Laverty +3 more
doaj +1 more source
Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses
Viruses, 2016 Several arenaviruses cause hemorrhagic fever (HF) disease in humans and pose an important public health problem in their endemic regions. To date, no Food and Drug Administration (FDA)-licensed vaccines are available to combat human arenavirus infections,
Luis Martínez-Sobrido +1 more
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Multi-color fluorescent reporter dengue viruses with improved stability for analysis of a multi-virus infection. [PDF]
PLoS ONE, 2018 Reporter virus is a versatile tool to visualize and to analyze virus infections. However, for flaviviruses, it is difficult to maintain the inserted reporter genes on the viral genome, limiting its use in several studies that require homogeneous virus ...
Amporn Suphatrakul +6 more
doaj +1 more source
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus
Microbiology Spectrum, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the highly contagious agent responsible for the coronavirus disease 2019 (COVID-19) pandemic.
Kevin Chiem +8 more
doaj +1 more source