Results 121 to 130 of about 8,602,059 (291)

Can we improve the health system with performance reporting? [PDF]

, 2014
Advanced healthcare systems are moving toward greater efficiency, transparency and accountability, and this trend will continue, particularly in fiscally-constrained environments There is no single measure that will improve service delivery and ...
Krister Partel
core  

Quality of systematic reviews and meta‐analyses in dermatology

Cochrane Evidence Synthesis and Methods
Introduction Although the number of published systematic reviews and meta‐analyses in dermatology has increased over the past decade, their quality is unknown.
Annapoorani Muthiah, Loch Kith Lee, John Koh, Ashly Liu, Aidan Tan   +4 more
doaj   +1 more source

Evidence under fire

Nordic Journal of Comparative and International Education
This systematic review examines what research on gamification in Ukrainian higher education shows about students' academic achievement, and what its designs and reporting allow a reader to conclude.
Oleksii Dotsenko
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Quality of randomized controlled trials and systematic reviews in pediatric surgery: A cross‐sectional meta‐research study

Cochrane Evidence Synthesis and Methods
Background There are few randomized controlled trials (RCTs) in pediatric surgery, and their risk of bias is unknown. There is also little known about the methodological or reporting quality of systematic reviews (with or without meta‐analyses) in ...
Wilson Jiang, Bill Wang, Sandro Sperandei, Aidan Christopher Tan   +3 more
doaj   +1 more source

Improving Clinical Practice Through Better Evidence: A Cross-Sectional Evaluation of the Reporting Quality in Contact Dermatitis Randomized Controlled Trial Abstracts

Cosmetics
Contact dermatitis is a highly prevalent inflammatory disease of the skin with substantial impact on patients’ quality of life and occupational function.
Mia Šušak Crnčević, Toni Durdov, Doris Rušić, Lara Ramić, Ana Ćosić, Josipa Bukić   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Improving Corporate Internet Reporting in China [PDF]

, 2014
For decades companies have disseminated information through traditional paper-based methods such as annual reports. This traditional method of reporting is limited by numerous issues and so cannot properly reflect the current state of the business world.
Liu, George
core