Results 1 to 10 of about 4,384,684 (303)

Electronic Versus Traditional Data Collection: A Multicenter Randomized Controlled Perioperative Pain Trial

Canadian Journal of Pain, 2019
Background: Electronic data collection is increasingly available as a means to collect pain-related clinical trial data; however, effectiveness and costs relative to traditional data collection are uncertain.
James S. Khan, Lindsay A. Jibb, Jason W. Busse, Ian Gilron, Stephen Choi, James E. Paul, Michael McGillion, Sean Mackey, D. Norman Buckley, Shun Fu Lee, P. J. Devereaux   +10 more
doaj   +1 more source

Risk of second primary cancers in cancer patients treated with cisplatin: a systematic review and meta-analysis of randomized studies

BMC Cancer, 2017
Background Case reports, retrospective analyses, and observational studies have linked the use of cisplatin to increased risk of second cancers, especially life-threatening secondary leukemia.
Fei Liang, Sheng Zhang, Hongxi Xue, Qiang Chen   +3 more
doaj   +1 more source

Interpreting Clinical Trial Results

CHEST Critical Care
Randomized clinical trials (RCTs) are the gold standard to evaluate intervention efficacy and effectiveness. To apply current, evidence-based interventions to daily practice, it is imperative that practicing intensivists be able to interpret the results ...
Christopher Kearney, MD, Brooke Barlow, PharmD, Brandon Pang, MD, Nicholas A. Bosch, MD   +3 more
doaj   +1 more source

Beyond Randomized Controlled Trials

Journal of Evidence-Based Complementary & Alternative Medicine, 2012
Complementary and alternative medicine is criticized by some as lacking evidence to support the effectiveness of its methods and medicines. Such critics typically point to mixed results from using randomized controlled trials to test complementary and ...
Isaac Golden PhD
doaj   +1 more source

Frequent fragility of randomized controlled trials for HCC treatment

BMC Cancer, 2021
Background The fragility index (FI) of trial results can provide a measure of confidence in the positive effects reported in randomized controlled trials (RCTs). The aim of this study was to calculate the FI of RCTs supporting HCC treatments.
Hao Zhang, Jingtao Li, Wenting Zeng
doaj   +1 more source

Clinical Trials Evaluating Drug Therapy: Types, Reliability of Results, Place in Modern Evidence-Based Medicine

Рациональная фармакотерапия в кардиологии, 2021
The article discusses the main methods of evidence in modern medicine. Special attention is paid to randomized controlled trials and observational studies. The advantages of randomized controlled trials over observational studies are considered.
S. Yu. Martsevich, N. P. Kutishenko, Yu. V. Lukina, M. M. Lukyanov, O. M. Drapkina   +4 more
doaj   +1 more source

Minoxidil versus placebo in the treatment of arterial wall hypertrophy in children with Williams Beuren Syndrome: a randomized controlled trial

BMC Pediatrics, 2019
Background Insufficient elastin synthesis leads to vascular complications and arterial hypertension in children with Williams-Beuren syndrome.
Behrouz Kassai, Philippe Bouyé, Brigitte Gilbert-Dussardier, François Godart, Jean-Benoit Thambo, Massimiliano Rossi, Pierre Cochat, Pierre Chirossel, Stephane Luong, André Serusclat, Isabelle Canterino, Catherine Mercier, Muriel Rabilloud, Christine Pivot, Fabrice Pirot, Tiphanie Ginhoux, Stéphanie Coopman, Guillaume Grenet, François Gueyffier, Sylvie Di-Fillippo, Aurélia Bertholet-Thomas   +20 more
doaj   +1 more source

Blindness in Randomized Controlled Trials [PDF]

International Journal of Fertility and Sterility, 2010
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important.
Mansour Shamsipour
doaj   +1 more source

Medical decision in COPD: the evidence-based history

Revista Portuguesa de Medicina Geral e Familiar, 2021
Randomized controlled trials together with systematic reviews and meta-analyses have been the cornerstone of clinical research. Some studies, because of the size of the sample, the use of randomization and well-defined measurements, the participation of
António Duarte-de-Araújo, Miguel Guimarães, Pedro Teixeira, Venceslau Hespanhol, Jaime Correia-de-Sousa   +4 more
doaj   +1 more source

Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience

Trials
Randomized controlled trials (RCTs) are the cornerstone of modern evidence-based medicine. They are considered essential to establish definitive evidence of efficacy and safety for new drugs, and whenever possible they should also be the preferred method
Sergio Buccheri, Stefan James, Marion Mafham, Martin Landray, Tom Melvin, Jonas Oldgren, Richard Bulbulia, Louise Bowman, Lotje Anna Hoogervorst, Perla J. Marang-van de Mheen, Peter Juni, Peter McCulloch, Alan G. Fraser   +12 more
doaj   +1 more source