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Design of Randomized Controlled Trials [PDF]
Circulation, 2007 A major factor in the rapid advance of medical science over the past 50 years has been the development and refinement of the clinical research method known as the randomized controlled trial (RCT). A clinical trial is defined as a prospective scientific experiment that involves human subjects in whom treatment is initiated for the evaluation of a ...
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Randomized controlled trials in resuscitation
Resuscitation PlusRandomized controlled trials (RCTs) are a gold standard in research and crucial to our understanding of resuscitation science. Many trials in resuscitation have had neutral findings, questioning which treatments are effective in cardiac resuscitation ...
Ian R. Drennan +2 more
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Randomized Controlled Trials [PDF]
Chest, 2020 Randomized controlled trials (RCTs) are considered the highest level of evidence to establish causal associations in clinical research. There are many RCT designs and features that can be selected to address a research hypothesis. Designs of RCTs have become increasingly diverse as new methods have been proposed to evaluate increasingly complex ...
Emily C, Zabor +2 more
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Understanding noninferiority trials [PDF]
Korean Journal of Pediatrics, 2012 Noninferiority trials test whether a new experimental treatment is not unacceptably less efficacious than an active control treatment already in use.
Seokyung Hahn
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The Randomized Controlled Trial [PDF]
Nephron Clinical Practice, 2009 Until recently, high-quality randomized controlled trials (RCTs) have rarely been performed in nephrology, because of several difficulties in conducting an RCT. The purpose of this article is to describe several issues related to the design and to the quality of RCTs in their conduct, analysis, interpretation, and reporting of the results.
Stel, Vianda S. +3 more
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Randomized controlled trials [PDF]
Phlebology: The Journal of Venous Disease, 2011 Proponents of evidence-based medicine would acknowledge that several sources of evidence inform clinical decision making. Hierarchies of evidence have, however, been developed to help describe the quality of evidence that may be found to answer our clinical questions. According to this classification, the randomized clinical trial is the most effective
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Randomized controlled trials in neurosurgery
Surgical Neurology International, 2022 Randomized controlled trials (RCTs) have become the standard method of evaluating new interventions (whether medical or surgical), and the best evidence used to inform the development of new practice guidelines. When we review the history of medical versus surgical trials, surgical RCTs usually face more challenges and difficulties when conducted ...
Takroni, Radwan +6 more
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PRECAF Randomized Controlled Trial [PDF]
Circulation: Arrhythmia and Electrophysiology, 2021 Background: We have previously shown that the presence of dual muscular coronary sinus (CS) to left atrial (LA) connections, coupled with rate-dependent unidirectional block in one limb, is associated with atrial fibrillation (AF) induction. This study sought to examine whether ablation of distal CS to LA connections at a first
Ling Kuo +7 more
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Trials, 2021 Introduction The Ebola virus disease (EVD) outbreak in 2014–2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine.
Moses Badio +25 more
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Randomized clinical trials related to urticaria: Bibliometric analysis from 2009 to 2019
National Journal of Physiology, Pharmacy and Pharmacology, 2020 Background: Urticaria is associated with considerable health-care costs. Randomized controlled trials (RCTs) are considered as the gold standard for evaluating efficacy in clinical research.
Anant D Patil
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