Results 31 to 40 of about 1,439,746 (305)

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

BMC Medicine, 2012
Background Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
Severus Emanuel, Seemüller Florian, Berger Michael, Dittmann Sandra, Obermeier Michael, Pfennig Andrea, Riedel Michael, Frangou Sophia, Möller Hans-Jürgen, Bauer Michael   +9 more
doaj   +1 more source

Frequent fragility of randomized controlled trials for HCC treatment

BMC Cancer, 2021
Background The fragility index (FI) of trial results can provide a measure of confidence in the positive effects reported in randomized controlled trials (RCTs). The aim of this study was to calculate the FI of RCTs supporting HCC treatments.
Hao Zhang, Jingtao Li, Wenting Zeng
doaj   +1 more source

Segmental stabilizing exercises and low back pain: What is the evidence? [PDF]

, 2006
Study design: A systematic review of randomized controlled trials. Objectives: To evaluate the effectiveness of segmental stabilizing exercises for acute, subacute and chronic low back pain with regard to pain, recurrence of pain, disability and ...
Bie, Rob de, Ewert, Thomas, Garnier, Katharina von, Limm, Heribert, Rackwitz, Berid, Stucki, Gerold   +5 more
core   +1 more source

Antibiotics in acute bronchitis: a meta-analysis. [PDF]

, 1999
PurposeMost patients with acute bronchitis who seek medical care are treated with antibiotics, although the effectiveness of this intervention is uncertain.
Bent, S, Grady, D, Saint, S, Vittinghoff, E   +3 more
core   +1 more source

Electronic Versus Traditional Data Collection: A Multicenter Randomized Controlled Perioperative Pain Trial

Canadian Journal of Pain, 2019
Background: Electronic data collection is increasingly available as a means to collect pain-related clinical trial data; however, effectiveness and costs relative to traditional data collection are uncertain.
James S. Khan, Lindsay A. Jibb, Jason W. Busse, Ian Gilron, Stephen Choi, James E. Paul, Michael McGillion, Sean Mackey, D. Norman Buckley, Shun Fu Lee, P. J. Devereaux   +10 more
doaj   +1 more source

Risk of second primary cancers in cancer patients treated with cisplatin: a systematic review and meta-analysis of randomized studies

BMC Cancer, 2017
Background Case reports, retrospective analyses, and observational studies have linked the use of cisplatin to increased risk of second cancers, especially life-threatening secondary leukemia.
Fei Liang, Sheng Zhang, Hongxi Xue, Qiang Chen   +3 more
doaj   +1 more source

Likelihood reweighting methods to reduce potential bias in noninferiority trials which rely on historical data to make inference

, 2013
It is generally believed that bias is minimized in well-controlled randomized clinical trials. However, bias can arise in active controlled noninferiority trials because the inference relies on a previously estimated effect size obtained from a ...
Chu, Jianxiong, Nie, Lei, Rubin, Daniel, Zhang, Zhiwei   +3 more
core   +1 more source

Interpreting Clinical Trial Results

CHEST Critical Care
Randomized clinical trials (RCTs) are the gold standard to evaluate intervention efficacy and effectiveness. To apply current, evidence-based interventions to daily practice, it is imperative that practicing intensivists be able to interpret the results ...
Christopher Kearney, MD, Brooke Barlow, PharmD, Brandon Pang, MD, Nicholas A. Bosch, MD   +3 more
doaj   +1 more source

Beyond Randomized Controlled Trials

Journal of Evidence-Based Complementary & Alternative Medicine, 2012
Complementary and alternative medicine is criticized by some as lacking evidence to support the effectiveness of its methods and medicines. Such critics typically point to mixed results from using randomized controlled trials to test complementary and ...
Isaac Golden PhD
doaj   +1 more source

Clinical Trials Evaluating Drug Therapy: Types, Reliability of Results, Place in Modern Evidence-Based Medicine

Рациональная фармакотерапия в кардиологии, 2021
The article discusses the main methods of evidence in modern medicine. Special attention is paid to randomized controlled trials and observational studies. The advantages of randomized controlled trials over observational studies are considered.
S. Yu. Martsevich, N. P. Kutishenko, Yu. V. Lukina, M. M. Lukyanov, O. M. Drapkina   +4 more
doaj   +1 more source