Results 51 to 60 of about 1,439,746 (305)

Assessing Cognitive Functioning in Children With Brain Tumors: Interaction of Neighborhood Social Determinants of Health and Neurological Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich, Manali Zope, Peter M. Fantozzi, Cassie N. Kline, Iris Paltin, Matthew C. Hocking   +5 more
wiley   +1 more source

Reporting of harm in randomized controlled trials evaluating stents for percutaneous coronary intervention [PDF]

, 2009
Background The aim of this study was to assess the reporting of harm in randomized controlled trials evaluating stents for percutaneous coronary intervention. Methods The study design was a methodological systematic review of randomized controlled trials.
Morgane Ethgen, Isabelle Boutron, Philippe Gabriel Steg, Carine Roy, Philippe Ravaud, PW Serruys, R Erbel, WH Maisel, JR Nebeker, AA Bavry, AA Bavry, A Farb, M Pfisterer, E Camenzind, PW Serruys, B Lagerqvist, A Kastrati, L Mauri, GW Stone, C Spaulding, R Tung, EP McFadden, JP Ioannidis, JP Ioannidis, PN Papanikolaou, M Ethgen, M Ethgen, I Boutron, U Naslund, DG Ives, KW Mahaffey, KW Mahaffey, KW Mahaffey, JA Cairns, AS Slutsky   +34 more
core   +4 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Factors affecting patient participation in orthopaedic trials comparing surgery to non-surgical interventions

Contemporary Clinical Trials Communications, 2016
Background: Randomized controlled trials (RCTs) are considered the most robust research design to determine the effectiveness of interventions. RCTs comparing surgery to non-surgical alternatives are particularly difficult to perform, partly due to ...
Rajat Mittal, Ian A. Harris, Sam Adie, Justine M. Naylor   +3 more
doaj   +1 more source

Blindness in Randomized Controlled Trials [PDF]

International Journal of Fertility and Sterility, 2010
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important.
Mansour Shamsipour
doaj   +1 more source

Acupuncture randomized trials (ART) in patients with chronic low back pain and osteoarthritis of the knee - Design and protocols [PDF]

, 2003
Background: We report on the study design and protocols of two randomized controlled trials (Acupuncture Randomized Trials = ART) that investigate the efficacy of acupuncture in the treatment of chronic low back pain and osteoarthritis of the knee ...
Becker-Witt, C., Brinkhaus, Benno, Hummelsberger, J., Irnich, D., Jena, S., Linde, K., Melchart, Dieter, Streng, A., Wagenpfeil, S., Willich, S. N.   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Medical decision in COPD: the evidence-based history

Revista Portuguesa de Medicina Geral e Familiar, 2021
Randomized controlled trials together with systematic reviews and meta-analyses have been the cornerstone of clinical research. Some studies, because of the size of the sample, the use of randomization and well-defined measurements, the participation of
António Duarte-de-Araújo, Miguel Guimarães, Pedro Teixeira, Venceslau Hespanhol, Jaime Correia-de-Sousa   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source