Results 61 to 70 of about 4,191,327 (298)

Two controlled trials to increase participant retention in a randomized controlled trial of mobile phone-based smoking cessation support in the United Kingdom. [PDF]

, 2011
BACKGROUND: Loss to follow-up of trial participants represents a threat to research validity. To date, interventions designed to increase participants' awareness of benefits to society of completing follow-up, and the impact of a telephone call from a ...
Free, Caroline, Rosemary Knight, Caroline Free, Edwards, Philip, Ettore Severi, Robertson, Steven, Severi, Ettore, Steven Robertson, Knight, Rosemary, Elizabeth Hoile, Philip Edwards, Hoile, Elizabeth   +11 more
core   +1 more source

Medical decision in COPD: the evidence-based history

Revista Portuguesa de Medicina Geral e Familiar, 2021
Randomized controlled trials together with systematic reviews and meta-analyses have been the cornerstone of clinical research. Some studies, because of the size of the sample, the use of randomization and well-defined measurements, the participation of
António Duarte-de-Araújo, Miguel Guimarães, Pedro Teixeira, Venceslau Hespanhol, Jaime Correia-de-Sousa   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Questions asked and answered in pilot and feasibility randomized controlled trials [PDF]

, 2011
Background In the last decade several authors have reviewed the features of pilot and feasibility studies and advised on the issues that should be addressed within them.
Shanyinde Milensu, Shanyinde, Milensu, Shanyinde, M, Weatherall, M., Weatherall, M, Mark Weatherall, Ruth M Pickering, Pickering, R.M., Shanyinde, M., Pickering Ruth M, Weatherall Mark, Pickering, RM, Milensu Shanyinde   +12 more
core   +2 more sources

Randomization in randomized clinical trials: From theory to practice

حیات, 2016
Background & Aim: Randomized clinical trials (RCTs) are studies which are able to provide the most valid evidence to compare various interventions in health research.
Mina Mohammady, Leila Janani
doaj  

Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience

Trials
Randomized controlled trials (RCTs) are the cornerstone of modern evidence-based medicine. They are considered essential to establish definitive evidence of efficacy and safety for new drugs, and whenever possible they should also be the preferred method
Sergio Buccheri, Stefan James, Marion Mafham, Martin Landray, Tom Melvin, Jonas Oldgren, Richard Bulbulia, Louise Bowman, Lotje Anna Hoogervorst, Perla J. Marang-van de Mheen, Peter Juni, Peter McCulloch, Alan G. Fraser   +12 more
doaj   +1 more source

Registration of published randomized trials: a systematic review and meta-analysis

BMC Medicine, 2018
Background Prospective trial registration is a powerful tool to prevent reporting bias. We aimed to determine the extent to which published randomized controlled trials (RCTs) were registered and registered prospectively.
Ludovic Trinquart, Adam G. Dunn, Florence T. Bourgeois   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The use of deception in public health behavioral intervention trials: a case study of three online alcohol trials. [PDF]

, 2013
Some public health behavioral intervention research studies involve deception. A methodological imperative to minimize bias can be in conflict with the ethical principle of informed consent.
Porter, John, Kypri, Kypros, McCambridge, Jim, Bendtsen, Preben, Kypri, Kypros,, Bendtsen, Preben,, McCambridge, Jim,, Porter, John,   +7 more
core   +1 more source

Evaluation of Randomized Controlled Trials [PDF]

Circulation, 2007
Although randomized controlled trials (RCTs) play a key role in modern medicine, considerable variability exists in their quality and in the reliability (reproducibility) of their results. The present article discusses features that characterize high-quality trials, such as intent-to-treat (ITT) analysis, the avoidance of patient exclusions, and a ...
openaire   +2 more sources