Results 81 to 90 of about 4,191,327 (298)

The effectiveness of alcohol screening and brief intervention in emergency departments: A multicentre pragmatic cluster randomized controlled trial [PDF]

, 2014
Background Alcohol misuse is common in people attending emergency departments (EDs) and there is some evidence of efficacy of alcohol screening and brief interventions (SBI).
Patton, Robert, Dale, V, Eileen Kaner (588847), Deluca Paolo, Drummond, Colin, Gilvarry Eilish, Eilish Gilvarry (588836), Newbury-Birch, Dorothy, Touquet Robin, Judy Myles (588839), Martin Bland (222260), Colin Drummond (339336), Mike Crawford, Cassidy, P, Deluca, Paolo; id_orcid, Patton, R, Bland, Martin, Shepherd Jonathan, Newbury-Birch Dorothy, Eileen Kaner, Adenekan Oyefeso, Myles Judy, Steve Parrott, Heather, Nick, Oyefeso, Adenekan, Parrott, Steve, Colin Drummond, Ruth McGovern, Katherine Perryman, Coulton, S, Patton Robert, Nick Heather (588837), Perryman, K, Paolo Deluca, Steve Parrott (588841), Dorothy Newbury-Birch (588840), Dale, Veronica, Myles, J, Cassidy, Paul, Tom Phillips, Godfrey Christine, Kaner, E, Newbury-Birch, D, Oyefeso, A, Cassidy Paul, Simon Coulton, Robin Touquet (588846), Drummond Colin, Heather Nick, Veronica Dale (588835), Jonathan Shepherd (588845), McGovern Ruth, Oyfeso, Adenekan, Touquet, R, Perryman Katherine, Shepherd, Jonathan, Parrott, S, Phillips, T, Veronica Dale, Paolo Deluca (588833), Christine Godfrey (227956), Paul Cassidy (588834), Ruth McGovern (588838), Adenekan Oyefeso (18454), Godfrey, Christine, Myles, Judy, Jonathan Shepherd, Robin Touquet, Parrott Steve, Christine Godfrey, Perryman, Katherine, Phillips, Tom, Oyefeso Adenekan, Katherine Perryman (588843), Tom Phillips (588844), Judy Myles, Drummond, C, Heather, N, Deluca, Paolo, Coulton, Simon, Coulton Simon, Kaner Eileen, Simon Coulton (167071), Newbury-Birch, Dorothy; id_orcid, Drummond, Colin; id_orcid, Nick Heather, Phillips Tom, Crawford, M, Dorothy Newbury-Birch, Mike Crawford (282626), Bland Martin, Crawford Mike, Dale Veronica, Touquet, Robin, Gilvarry, Eilish, Kaner, Eileen, Robert Patton (588842), McGovern, Ruth, McGovern, R, Patton, Bob, Martin Bland, Crawford, Mike, Torquet, Robin, Robert Patton, Shepherd, J, Philips, Tom, Gilvarry, E, Eilish Gilvarry, Deluca, P, Godfrey, C, Paul Cassidy, Bland, M   +111 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Intervention description is not enough: evidence from an in-depth multiple case study on the untold role and impact of context in randomised controlled trials of seven complex interventions [PDF]

, 2012
Background: A number of single case reports have suggested that the context within which intervention studies take place may challenge the assumptions that underpin randomised controlled trials (RCTs).
Brian Williams, Williams Brian, Treweek Shaun, Shaun Treweek, Taylor, Julie; id_orcid, Coyle Joanne, Taylor, Julie, Wells, Mary, Wells Mary, Mary Wells, Coyle, Joanne, Williams, Brian, Taylor Julie, Julie Taylor, Joanne Coyle, Treweek, Shaun   +15 more
core   +2 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A Primer on Randomized Controlled Trials

The Journal of ExtraCorporeal Technology, 2006
Randomized Clinical Trials are held as the gold standard for quantifying the effect of an intervention across two or more groups. In such a trial an intervention is randomly allocated to one of two groups. The benefit of such a trial lies in its ability to establish nearly comparable groups of subjects in all manner except for the effect of the ...
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Selective Trials: A Principal-Agent Approach to Randomized Controlled Experiments [PDF]

We study the design of randomized controlled experiments in environments where outcomes are significantly affected by unobserved effort decisions taken by the subjects(agents). While standard randomized controlled trials (RCTs) are internally consistent,
Erik Snowberg, Gerard Padro i Miquel, Sylvain Chassang   +2 more
core  

What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies. [PDF]

, 2006
National Coordinating Centre for Research Methodology; Medical Research Council, UK Department of Health; Chief Scientist OfficeNot peer reviewedPublisher ...
McDonald, AM, Campbell, MK, Jonathan A Cook, Elbourne, DR, Cook, Jonathan Alistair, Francis, D, McDonald, Alison Mary, Francis, David, Knight, R.C, Knight, RC, Knight, Rosemary, McDonald, A.M, Grant, Adrian, Garcia Jo, McDonald, A, Cook, J, McDonald Alison M, Francis, David; id_orcid, McDonald, Alison M, Vikki A Entwistle, Campbell, Marion K, Rosemary C Knight, Snowdon Claire, Entwistle, V.A, Campbell, Marion K., Francis David, Entwistle, Vicky, Grant Adrian M, Knight, Rosemary C, Entwistle Vikki A, Cook, Jonathan A, Roberts, Ian, Cook, J.A, Grant, AM, Campbell, Marion, Cook, JA, Entwistle, Vikki A., Elbourne, D.R, Entwistle, Vikki, Campbell, Marion Kay, Snowdon, Claire, Grant, Adrian M, Garcia, J, David Francis, Elbourne, Diana, Diana R Elbourne, Alison M McDonald, Elbourne, Diana R., McDonald, Alison M., Roberts Ian, Elbourne, Diana R, Grant, Adrian Maxwell, Campbell Marion K, Entwistle, Vikki A, Snowdon, C, Campbell, M.K, Grant, Adrian M., Cook Jonathan A, Knight, Rosemary C., Garcia, Jo, Adrian M Grant, Ian Roberts, Entwistle, VA, Claire Snowdon, Grant, A.M, Marion K Campbell, Knight Rosemary C, Jo Garcia, Elbourne Diana R, Roberts, I, Cook, Jonathan A.   +70 more
core   +4 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source