Results 101 to 110 of about 4,191,327 (298)

Contamination in trials of educational interventions [PDF]

, 2007
Objectives: To consider the effects of contamination on the magnitude and statistical significance (or precision) of the estimated effect of an educational intervention, to investigate the mechanisms of contamination, and to consider how contamination ...
Keogh-Brown, M.R., Bachmann, M.O., Ramsay, Craig R, Hewitt, C., Campbell, M.J., Torgerson, D.J., Miles, J.N.V., Howe, A., Shepstone, L., Elbourne, Diana R., Song, F, Harvey, I., Miles, S.   +12 more
core   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Realist randomised controlled trials: a new approach to evaluating complex public health interventions. [PDF]

, 2012
Randomized trials of complex public health interventions generally aim to identify what works, accrediting specific intervention 'products' as effective.
Bonell, C., Morton, M., Fletcher, Adam, Moore, L., Fletcher, A., Bonell, Chris, Lorenc, T., Lorenc, Theo, Moore, Laurence, Morton, Matthew   +9 more
core   +1 more source

Acupuncture Treatment for Restless Legs Syndrome: A Review of Randomized Controlled Trials

Journal of Acupuncture Research, 2023
To determine the effectiveness of acupuncture in treating restless legs syndrome (RLS), we conducted a literature review of randomized controlled trials (RCTs) that utilized acupuncture as an intervention for patients diagnosed with RLS.
Go Eun Chae, Hyun Woo Kim, Hye Jeong Jo, Ahra Koh, Young Jin Lee, Ji Eun Choi, Woo Young Kim   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mental practice with motor imagery in stroke recovery: randomized controlled trial of efficacy [PDF]

, 2011
This randomized controlled trial evaluated the therapeutic benefit of mental practice with motor imagery in stroke patients with persistent upper limb motor weakness.
Scott, Clare L, Sara Joice, Clare L. Scott, Marie Johnston, Ietswaart, Magdalena, Dijkerman, H Chris, Scott, Claire, H. Chris Dijkerman, Dijkerman, H. Chris, Steven J.C. Hamilton, MacWalter, Ronald, Hamilton, Steven, MacWalter, Ronald S., Johnston, Marie, Magdalena Ietswaart, MacWalter, Ronald S, Ronald S. MacWalter, Joice, Sara, Scott, Clare L., Hamilton, Steven J. C., Hamilton, Steven J C   +20 more
core   +1 more source

Phototherapy Alone or Combined with Adjuvant Drugs for Neonatal Hyperbilirubinemia: A Systematic Review and Network Meta-Analysis

Children
Objectives: Neonatal hyperbilirubinemia is a common disease in the neonatal period. In this meta-analysis, we aim to evaluate the efficacy of adjuvant drugs combined with phototherapy in the treatment of neonatal hyperbilirubinemia.
Qiang Fei, Huazi Liu, Xinning Wang, Tianming Yuan   +3 more
doaj   +1 more source

Revisiting the Randomized Controlled Trial

Pakistan Journal of Medical Sciences, 2017
doi: https://doi.org/10.12669/pjms.333.13221How to cite this:Zulfiqar H. Revisiting the Randomized Controlled Trial. Pak J Med Sci. 2017;33(3):517-518.   doi: https://doi.org/10.12669/pjms.333.13221This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which ...
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source