Results 111 to 120 of about 836,047 (311)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A framework for Surgical Quality Assurance (SQA) in randomized controlled trials in gastrointestinal surgery: an international Delphi consensus studyResearch in context

EClinicalMedicine
Summary: Background: Randomized controlled trials (RCTs) in gastrointestinal surgery often lack standardized approaches to Surgical Quality Assurance (SQA), which threatens both internal and external validity. The technical complexity and inherent inter-
Dillen C. van der Aa, Sofie P.G. Henckens, Hendrik Jaap Bonjer, Jurriaan B. Tuynman, Marc G. Besselink, Natalie S. Blencowe, Goerge B. Hanna, Mark I. van Berge Henegouwen, Sheraz R. Markar, Suzanne S. Gisbertz   +9 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Randomized Controlled Trials in Dentistry

Essentials of Dentistry
: Randomized Controlled Trials (RCTs), acknowledged as a source of evidence regarding the feasibility of an initiative, are considered secondary level evidence for decisions in practice.
Doğa Naz Bahçeci, Selin Saygılı, Yelda Kasımoğlu   +2 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Blinding and bias in randomized controlled trials: when to measure the effectiveness of blinding

, 2019
EDITOR–A recent letter by Hastings‐Ison and Graham1 considered three randomized controlled trials (RCTs) that report the outcome of botulinum neurotoxin A (BoNT‐A) injections in children with cerebral palsy (CP), and asserted that they were not ...
Copeland, L, Thorley, M, Kentish, M, Edwards, P, Boyd, RN, Sakzewski, L, Ware, RS   +6 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Randomized controlled trials in CMI [PDF]

Clinical Microbiology and Infection, 2018
L, Leibovici, M, Paul
openaire   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Modifiable determinants of older adults’ physical activity and sedentary behavior in community and healthcare settings: a DE-PASS systematic review and meta-analysis

European Review of Aging and Physical Activity
Objectives To identify the modifiable determinants targeted in interventions involving older adults, and to determine which of these interventions effectively increased physical activity (PA) and/or reduced sedentary behaviour (SB).
Simone Ciaccioni, Sofie Compernolle, Maren Lerfald, Federico Palumbo, Floriana Fadda, Ginevra Toma, Selcuk Akpinar, Katja Borodulin, Emine Caglar, Greet Cardon, Murat Cenk Celen, Joanna Cieślińska-Świder, Cristina Cortis, Andrea Di Credico, Murat Emirzeoğlu, Andrea Fusco, Daniel Gallardo Gómez, Linn Marita Hagen, Ayda Karaca, Mohammed Khudair, Marianna De Maio, Paul Jarle Mork, Livia Oddi, Kandianos Emmanouil Sakalidis, Petru Sandu, Sevil Turhan, Wei Wang, Melda Pelin Yargıç, Ekaterina Zotcheva, Laura Capranica, Ciaran MacDonncha, Linda Ernstsen   +31 more
doaj   +1 more source