Results 121 to 130 of about 836,047 (311)

Meta-analysis of Randomized Controlled Trials

Philippine Journal of Orthopaedics
Background. Anterior cruciate ligament (ACL) injuries are prevalent among younger demographics due to sportsrelated incidents, contributing to knee joint instability.
Leinard Palpal-latoc, Carmelo Braganza
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Characteristics of included randomized controlled trials.

, 2019
Characteristics of included randomized controlled trials.
Liwen Feng (6383711), Wei Fan (109074), Kailai Nie (6383708), Hui Jiang (102809)   +3 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Randomized controlled trials : questions, answers, and musings /

, 2007
Rev ed. of: Randomised controlled trials / Alejandro R. Jadad. 1998.Includes bibliographical references and index.Randomized controlled trials: the basics -- Types of randomized controlled trials -- Bias in randomized controlled trials -- Assessing the ...
Jadad, Alejandro R.,, Enkin, Murray,
core  

Randomized controlled trials - a matter of design.

Neuropsychiatric disease and treatment, 2016
Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle
Spieth, Peter Markus, Kubasch, Anne Sophie, Penzlin, Ana Isabel, Barlinn, Kristian, Siepmann, Timo, Illigens, Ben   +5 more
openaire   +5 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Summary of included randomized controlled trials.

, 2019
Summary of included randomized controlled trials.
Joy C. MacDermid (4279753), Dianne Bryant (6652271), George S. Athwal (6751649), Goris Nazari (4874380)   +3 more
core   +1 more source

Components of effective randomized controlled trials of hydrotherapy programs for fibromyalgia syndrome: A systematic review

Journal of Pain Research, 2009
Luke Perraton, Zuzana Machotka, Saravana KumarInternational Centre for Allied Health Evidence, University of South Australia, Adelaide, South Australia, AustraliaAim: Previous systematic reviews have found hydrotherapy to be an effective management ...
Luke Perraton, Zuzana Machotka, Saravana Kumar   +2 more
doaj  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source