Results 121 to 130 of about 1,439,746 (305)

Immunogenicity of WHO-17D and Brazilian 17DD yellow fever vaccines: a randomized trial

Revista de Saúde Pública, 2004
OBJECTIVE: To compare the immunogenicity of three yellow fever vaccines from WHO-17D and Brazilian 17DD substrains (different seed-lots). METHODS: An equivalence trial was carried out involving 1,087 adults in Rio de Janeiro.
Camacho Luiz Antonio Bastos, Freire Marcos da Silva, Leal Maria da Luz Fernandes, Aguiar Savitri Gomes de, Nascimento Jussara Pereira do, Iguchi Takumi, Lozana José de Azevedo, Farias Roberto Henrique Guedes   +7 more
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Meta-analysis of Randomized Controlled Trials

Philippine Journal of Orthopaedics
Background. Anterior cruciate ligament (ACL) injuries are prevalent among younger demographics due to sportsrelated incidents, contributing to knee joint instability.
Leinard Palpal-latoc, Carmelo Braganza
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Modifiable determinants of older adults’ physical activity and sedentary behavior in community and healthcare settings: a DE-PASS systematic review and meta-analysis

European Review of Aging and Physical Activity
Objectives To identify the modifiable determinants targeted in interventions involving older adults, and to determine which of these interventions effectively increased physical activity (PA) and/or reduced sedentary behaviour (SB).
Simone Ciaccioni, Sofie Compernolle, Maren Lerfald, Federico Palumbo, Floriana Fadda, Ginevra Toma, Selcuk Akpinar, Katja Borodulin, Emine Caglar, Greet Cardon, Murat Cenk Celen, Joanna Cieślińska-Świder, Cristina Cortis, Andrea Di Credico, Murat Emirzeoğlu, Andrea Fusco, Daniel Gallardo Gómez, Linn Marita Hagen, Ayda Karaca, Mohammed Khudair, Marianna De Maio, Paul Jarle Mork, Livia Oddi, Kandianos Emmanouil Sakalidis, Petru Sandu, Sevil Turhan, Wei Wang, Melda Pelin Yargıç, Ekaterina Zotcheva, Laura Capranica, Ciaran MacDonncha, Linda Ernstsen   +31 more
doaj   +1 more source

Randomized controlled trials in resuscitation

Resuscitation Plus
Randomized controlled trials (RCTs) are a gold standard in research and crucial to our understanding of resuscitation science. Many trials in resuscitation have had neutral findings, questioning which treatments are effective in cardiac resuscitation ...
Ian R. Drennan, Shelley L. McLeod, Sheldon Cheskes   +2 more
doaj   +1 more source

What is the best way to manage benign paroxysmal positional vertigo? [PDF]

, 2003
A simple repositioning maneuver, such as the Epley maneuver, performed by an experienced clinician, can provide symptom relief from benign paroxysmal positional vertigo (BPPV) lasting at least 1 month (strength of recommendation [SOR]: A, systematic ...
Russell, Roger G., Strickland, Carmen
core  

A Closer Look at Exclusion Criteria in Randomized Controlled Psychotherapy Trials for Adult Depression [PDF]

, 2020
A common concern regarding clinical trials evaluating treatments for depression is findings may not generalize to the population of interest due to the use of restrictive exclusion criteria.
Schenk, Anneliese
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source