Results 71 to 80 of about 1,439,746 (305)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
BMC Pediatrics, 2019 Background Insufficient elastin synthesis leads to vascular complications and arterial hypertension in children with Williams-Beuren syndrome.
Behrouz Kassai +20 more
doaj +1 more source
Matching on-the-fly in Sequential Experiments for Higher Power and Efficiency [PDF]
, 2013 We propose a dynamic allocation procedure that increases power and efficiency when measuring an average treatment effect in sequential randomized trials.
Kapelner, Adam, Krieger, Abba
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Selective serotonin reuptake inhibitors in the treatment of generalized anxiety disorder [PDF]
, 2002 Selective serotonin reuptake inhibitors have proven efficacy in the treatment of panic disorder, obsessive–compulsive disorder, post-traumatic stress disorder and social anxiety disorder.
Allgulander C +41 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
The use of homeopathy in veterinary medicine: a systematic review
Semina: Ciências AgráriasAlthough its use remains controversial, homeopathy has been proposed as an integrative approach alongside conventional medicine. This systematic review aimed to validate the use of homeopathy in veterinary using randomized controlled trials as the gold ...
Isabela Cristina Colaço Bez +6 more
doaj +1 more source
Are inhalers with spacers better than nebulizers for children with asthma? [PDF]
, 2004 Metered-dose inhalers with a spacer (MDI/S) are as good as, or better than, nebulizers for children with asthma. This is based on numerous randomized controlled trials that compared outcomes such as hospital admission rates, asthma severity scores, and ...
Hsu, Julian T., Parker, Sandi
core
A simplified guide to randomized controlled trials. [PDF]
, 2018 A randomized controlled trial (RCT) is a prospective, comparative, quantitative study/experiment performed under controlled conditions with random allocation of interventions to comparison groups.
Acharya, G, Bhide, A, Shah, PS
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source