Results 41 to 50 of about 836,047 (311)
Frequent fragility of randomized controlled trials for HCC treatment
BMC Cancer, 2021 Background The fragility index (FI) of trial results can provide a measure of confidence in the positive effects reported in randomized controlled trials (RCTs). The aim of this study was to calculate the FI of RCTs supporting HCC treatments.
Hao Zhang, Jingtao Li, Wenting Zeng
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Interpreting Clinical Trial Results
CHEST Critical CareRandomized clinical trials (RCTs) are the gold standard to evaluate intervention efficacy and effectiveness. To apply current, evidence-based interventions to daily practice, it is imperative that practicing intensivists be able to interpret the results ...
Christopher Kearney, MD +3 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2021 The article discusses the main methods of evidence in modern medicine. Special attention is paid to randomized controlled trials and observational studies. The advantages of randomized controlled trials over observational studies are considered.
S. Yu. Martsevich +4 more
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Alternatives to the Randomized Controlled Trial
American Journal of Public Health, 2008 Public health researchers are addressing new research questions (e.g., effects of environmental tobacco smoke, Hurricane Katrina) for which the randomized controlled trial (RCT) may not be a feasible option. Drawing on the potential outcomes framework (Rubin Causal Model) and Campbellian perspectives, we consider alternative research ...
Stephen G, West +10 more
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Analysis of Randomized Controlled Trials [PDF]
Epidemiologic Reviews, 2002 Although the sophistication and flexibility of the statistical technology available to the data analyst have increased, some durable, simple principles remain valid. Hypothesis-driven analyses, which were anticipated and specified in the protocol, must still be kept separate and privileged relative to the important, but risky data mining made possible ...
Peter, Peduzzi +3 more
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, 2018 Background: Spasticity is a common post-stroke complication, and it results in substantial deterioration in the quality of life of patients. Although potential positive effects of warm-needle moxibustion on spasticity after stroke have been observed ...
Chen, Jin-Xiu +13 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Tyranny of a "Randomized Controlled Trials"
Surgical Neurology International, 2012 “Evidence-based medicine” is a popular concept that simply means basing clinical decisions on best available scientific evidence. The idea appears very sensible and attractive – who would not want to be treated according to the best scientific evidence? As usual, complexity lurks just below the surface.
openaire +3 more sources