Results 41 to 50 of about 4,191,327 (298)

Interpreting Randomized Controlled Trials

Cancers, 2023
This article describes rationales and limitations for making inferences based on data from randomized controlled trials (RCTs). We argue that obtaining a representative random sample from a patient population is impossible for a clinical trial because patients are accrued sequentially over time and thus comprise a convenience sample, subject only to ...
Pavlos Msaouel, Juhee Lee, Peter F Thall
openaire   +2 more sources

A statistical framework for quantifying clinical equipoise for individual cases during randomized controlled surgical trials [PDF]

, 2011
Background Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are ...
Girling, Alan, Girling Alan, Parsons, Nicholas R., Parsons, NR, Alan Girling, Griffin Damian, Girling, Alan J., Yuri Kulikov, Kulikov Yuri, Damian Griffin, Parsons Nicholas R, Griffin, Damian R., Griffin, D, Kulikov, Y, Kulikov, Yuri, Nicholas R Parsons   +15 more
core   +2 more sources

Interpreting Clinical Trial Results

CHEST Critical Care
Randomized clinical trials (RCTs) are the gold standard to evaluate intervention efficacy and effectiveness. To apply current, evidence-based interventions to daily practice, it is imperative that practicing intensivists be able to interpret the results ...
Christopher Kearney, MD, Brooke Barlow, PharmD, Brandon Pang, MD, Nicholas A. Bosch, MD   +3 more
doaj   +1 more source

Strategies to improve recruitment to randomised controlled trials [PDF]

, 2010
Background Recruiting participants to trials can be extremely difficult. Identifying strategies that improve trial recruitment would benefit both trialists and health research.
Marie Pitkethly, Jones, R, Elizabeth Mitchell, Cook, Jonathan, Shaun Treweek, Treweek, S, Wilson, S, Kjeldstrøm, M, Kjeldstrom, Monica, Sue Wilson, Taskila, T, Johansen, Marit, Cook, J, Lockhart, Pauline, Taskila, Taina, Pauline Lockhart, Pitkethly, Marie, Taskil, T, Kjeldstrom, M, Treweek, Shaun, Sullivan, F, Cook, JAC, Jackson, Catherine Miriam, Monica Kjeldstrøm, Marit Johansen, Mitchell, Elizabeth, Taina K Taskila, Mitchell, E, Sullivan, Frank, Jackson, Catherine, Taskila, Taina K., Johansen, M, Catherine Jackson, Ritu Jones, Wilson, Sue, Mitchell, Lizabeth, Frank Sullivan, Jackson, C, Taina Taskila, Jones, Ritu, Pitkethly, M, Jonathan Cook   +41 more
core   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Process evaluation in randomised controlled trials of complex interventions. [PDF]

, 2006
Most randomised controlled trials focus on outcomes, not on the processes involved in implementing an intervention. Using an example from school based health promotion, this paper argues that including a process evaluation would improve the science of ...
Allen, Elizabeth, Strange, V, Bonell, Chris, Bonell, C, Stephenson, J, Oakley, A, RIPPLE Study Team, Stephenson, Judith, Allen, E, Oakley, Ann, Strange, Vicki   +10 more
core   +1 more source

Alternatives to the Randomized Controlled Trial

American Journal of Public Health, 2008
Public health researchers are addressing new research questions (e.g., effects of environmental tobacco smoke, Hurricane Katrina) for which the randomized controlled trial (RCT) may not be a feasible option. Drawing on the potential outcomes framework (Rubin Causal Model) and Campbellian perspectives, we consider alternative research ...
Stephen G, West, Naihua, Duan, Willo, Pequegnat, Paul, Gaist, Don C, Des Jarlais, David, Holtgrave, José, Szapocznik, Martin, Fishbein, Bruce, Rapkin, Michael, Clatts, Patricia Dolan, Mullen   +10 more
openaire   +3 more sources

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

Efficacy of Early Neonatal Vitamin A Supplementation in Reducing Mortality During Infancy in Ghana, India and Tanzania: Study Protocol for a Randomized Controlled Trial. [PDF]

, 2012
Vitamin A supplementation of 6-59 month old children is currently recommended by the World Health Organization based on evidence that it reduces mortality.
Honorati Masanja, Fontaine Olivier, Bahl, Rajiv, Dube Brinda, Rajiv Bahl, Oleary Maureen, Taneja, Sunita, Fawzi Wafaie, Msham Salum, Martines Jose, NEOVITA Study Author Group, Kirkwood, BR, Bhandari, Nita, Oleary, M, Sam Newton, Salum Msham, Newton Sam, Bhandari, N, Brinda Dube, Bahl, R, Emily Smith, Dube, Brinda, Fawzi, W, Mazumder, S, Sarmila Mazumder, Oleary, Maureen, Shannon, C, Kirkwood Betty R, Betty R Kirkwood, Martines, J, Taneja Sunita, Msham, Salum, Jose Martines, Masanja, H, null null, Olivier Fontaine, Msham, S, Mazumder, Sarmila, Fontaine, O, Nita Bhandari, Edmond, Karen, Ruben, Julia, Sunita Taneja, Kaur Jasmine, Wafaie Fawzi, Smith, E, Masanja Honorati, Taneja, S, Ruben Julia, Yoshida, Sachiyo, Bhandari Nita, Karen Edmond, Caitlin Shannon, Fontaine, Olivier, Smith Emily, Maureen Oleary, Kaur, Jasmine, Ruben, J, Julia Ruben, Fawzi, Wafaie, Newton, S, Newton, Sam, Edmond Karen, Mazumder Sarmila, Martines, Jose, Kirkwood, Betty R., Kirkwood, Betty R, Bahl Rajiv, Jasmine Kaur, Shannon Caitlin, Edmond, K, Sachiyo Yoshida, Masanja, Honorati, Shannon, Caitlin, Smith, Emily, Dube, B, Yoshida, S, Kaur, J, Yoshida Sachiyo   +78 more
core   +2 more sources

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source