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A randomized controlled trial is perhaps the only research method which enables researchers to investigate whether cause and effect relationships exist between factors being studied. This article outlines some of the principles underpinning this method and illustrates these with examples taken from an antenatal study of the treatment of women with ...
R C N Williamson +4 more
openaire +2 more sources
Economic compensation interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review and meta-analysis. [PDF]
BackgroundEconomic compensation interventions may help support higher voluntary medical male circumcision (VMMC) coverage in priority sub-Saharan African countries.
Atkins, Kaitlyn +8 more
core +1 more source
How necessary are randomized controlled trials? [PDF]
Randomized controlled trials (RCTs) are often deemed the gold standard for testing new treatments. This belief in turn justifies recruiting patients into such trials even when it is suspected that a new treatment is superior – although patients in the ...
Northcott, Robert
core
Bias and Sensitivity Analysis When Estimating Treatment Effects from the Cox Model with Omitted Covariates [PDF]
Omission of relevant covariates can lead to bias when estimating treatment or exposure effects from survival data in both randomized controlled trials and observational studies. This paper presents a general approach to assessing bias when covariates are
Henley, William Edward +2 more
core +2 more sources
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior +7 more
wiley +1 more source
Introduction: Cardiovascular disease is one of the biggest causes of death in the world. Hypertension is known as a major risk factor for morbidity and mortality in cardiovascular disease. Adherence to treatment is very important to overcome the problem,
superzeki Zaidatul Fadilah +3 more
doaj +1 more source
Does taking vitamin, mineral and fatty acid supplements prevent cognitive decline? A systematic review of randomized controlled trials [PDF]
Background Observational studies have shown associations between nutritional status and cognition in later life but evidence from intervention studies is unclear.
Avenell, Alison, Jia, X, McNeill, G
core +1 more source
Additional Physical Interventions to Conventional Physical Therapy in Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials [PDF]
Parkinson's disease (PD) represents the second most common neurodegenerative disease. Currently, conventional physical therapy is complemented by additional physical interventions with recreational components, improving different motor conditions in ...
Heredia Rizo, Alberto-Marcos +4 more
core +2 more sources
ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian +7 more
wiley +1 more source
Registration of published randomized trials: a systematic review and meta-analysis
Background Prospective trial registration is a powerful tool to prevent reporting bias. We aimed to determine the extent to which published randomized controlled trials (RCTs) were registered and registered prospectively.
Ludovic Trinquart +2 more
doaj +1 more source

