Results 11 to 20 of about 1,439,746 (305)

Impact of the COVID-19 Pandemic on Non-COVID-19 Clinical Trials

open access: yesJournal of Cardiovascular Development and Disease, 2022
Randomized controlled trials (RCT) were impacted by the COVID-19 pandemic, but no systematic analysis has evaluated the overall impact of COVID-19 on non-COVID-19-related RCTs. The ClinicalTrials.gov database was queried in February 2020.
Katia Audisio   +13 more
doaj   +1 more source

Evolving targets for heart failure: the journey so far

open access: yesGlobal Cardiology, 2023
The treatment of heart failure has included vasodilators, positive inotropes and most successfully neurohormonal blockade. Recent research has looked at metabolic and immune modulatory approaches, and implantable, mainly electrical devices.
Giuseppe M.C. Rosano, Jerneja Farkas
doaj   +1 more source

Commentary of "Placebo Studies in Developing Countries: Ethical, but not Ideal"

open access: yesVoices in Bioethics, 2014
In his piece, Scott is against the notion that using placebos as controls (when there is an existing treatment method) in randomized controlled trials (RCTs) is never ethical.
Marilyn Eshikena
doaj   +1 more source

Precision oncology: the intention-to-treat analysis fallacy. [PDF]

open access: yes, 2020
It has recently been suggested that precision oncology studies should be reanalysed using the intention-to-treat (ITT) methodology developed for randomized controlled clinical trials.
Kato, Shumei   +3 more
core   +1 more source

Factors influencing the enrollment in randomized controlled trials in orthopedics

open access: yesContemporary Clinical Trials Communications, 2017
Background: Low enrollment rates are a threat to the external validity of clinical trials. The purpose of this study was to identify factors associated with lower enrollment rates in randomized controlled trials (RCTs) involving orthopedic procedures ...
Christopher T. Lim   +4 more
doaj   +1 more source

TRUST Study: Participation in Randomized Controlled Trials and Subsequent Adherence to Visiting Medical Institutions and Taking Medications in Patients with Cardiovascular Diseases. Part II. Assessment of the Quality of Therapy

open access: yesРациональная фармакотерапия в кардиологии, 2020
Aim. Based on the data of the TRUST study (Influence of Participation in Randomized Controlled Trials on adheRence to Medicines' Intake and regUlar viSits to the docTor) to assess the quality of drug therapy and patients' awareness of achieving target ...
N. O. Vasyukova   +4 more
doaj   +1 more source

Fecal incontinence: the quality of reported randomized, controlled trials in the last ten years. [PDF]

open access: yes, 2008
This study was designed to analyze the characteristics and the quality of reporting of randomized, controlled trials published during the last ten years on fecal ...
Chelvanayagam, Sonya   +2 more
core   +1 more source

Effect of the telemedicine-supported multicomponent exercise therapy in patients with knee osteoarthritis: study protocol for a randomized controlled trial

open access: yesTrials, 2023
Introduction The rising prevalence of knee osteoarthritis is placing a considerable strain on the global healthcare system. To address this issue, telemedicine-supported multicomponent exercise therapy has emerged as a promising approach.
Yuan Feng   +9 more
doaj   +1 more source

From wealth to health: evaluating microfinance as a complex intervention [PDF]

open access: yes, 2017
Innovative interventions that address the social determinants of health are required to help reduce persistent health inequalities. We argue that microcredit can act in this way and develop a conceptual framework from which to examine this.
Biosca , Olga   +2 more
core   +1 more source

Analysis of the characteristics and the degree of pragmatism exhibited by pragmatic-labelled trials of antineoplastic treatments

open access: yesBMC Medical Research Methodology, 2023
Background Pragmatic clinical trials (PCTs) are designed to reflect how an investigational treatment would be applied in clinical practice. As such, unlike their explanatory counterparts, they measure therapeutic effectiveness and are capable of ...
Robbe Saesen   +6 more
doaj   +1 more source

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