Results 11 to 20 of about 4,191,327 (298)

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]

BMC Medicine, 2012
Background Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
Severus Emanuel, Seemüller Florian, Berger Michael, Dittmann Sandra, Obermeier Michael, Pfennig Andrea, Riedel Michael, Frangou Sophia, Möller Hans-Jürgen, Bauer Michael   +9 more
doaj   +3 more sources

How necessary are randomized controlled trials? [PDF]

, 2012
Randomized controlled trials (RCTs) are often deemed the gold standard for testing new treatments. This belief in turn justifies recruiting patients into such trials even when it is suspected that a new treatment is superior – although patients in the ...
Northcott, Robert
core   +7 more sources

PRECAF Randomized Controlled Trial [PDF]

Circulation: Arrhythmia and Electrophysiology, 2021
Background: We have previously shown that the presence of dual muscular coronary sinus (CS) to left atrial (LA) connections, coupled with rate-dependent unidirectional block in one limb, is associated with atrial fibrillation (AF) induction. This study sought to examine whether ablation of distal CS to LA connections at a first
Ling Kuo, David S. Frankel, Aung Lin, Jeffrey Arkles, Matthew Hyman, Pasquale Santangeli, Francis E. Marchlinski, Saman Nazarian   +7 more
openaire   +2 more sources

Mapping multicenter randomized controlled trials in anesthesiology: a scoping review

Systematic Reviews, 2021
Background Evidence suggests that there are substantial inconsistencies in the practice of anesthesia. There has not yet been a comprehensive summary of the anesthesia literature that can guide future knowledge translation interventions to move evidence ...
Sylvain Boet, Joseph K. Burns, Olivia Cheng-Boivin, Hira Khan, Kendra Derry, Deric Diep, Abdul Hadi Djokhdem, Sung Wook Um, Johnny W. Huang, Danica Paré, Mimi Deng, Liza Begunova, Linda Yi Ning Fei, Maryam Bezzahou, Pium Sonali Andrahennadi, Elysia Grose, Ruth G Abebe, Fadi Mansour, Zoé Talbot, Pierre-Marc Dion, Manvinder Kaur, Cole Etherington   +21 more
doaj   +1 more source

Impact of the COVID-19 Pandemic on Non-COVID-19 Clinical Trials

Journal of Cardiovascular Development and Disease, 2022
Randomized controlled trials (RCT) were impacted by the COVID-19 pandemic, but no systematic analysis has evaluated the overall impact of COVID-19 on non-COVID-19-related RCTs. The ClinicalTrials.gov database was queried in February 2020.
Katia Audisio, Hillary Lia, Newell Bryce Robinson, Mohamed Rahouma, Giovanni Soletti, Gianmarco Cancelli, Roberto Perezgrovas Olaria, David Chadow, Derrick Y. Tam, Dominique Vervoort, Michael E. Farkouh, Deepak L. Bhatt, Stephen E. Fremes, Mario Gaudino   +13 more
doaj   +1 more source

The Effectiveness of Budesonide in the Treatment of Asthma Attacks in Children: A Systematic Review and Meta-Analysis [PDF]

Preventive Care in Nursing and Midwifery Journal, 2023
Background: Severe and moderate asthma attacks are among the major causes of children’s visits to emergency departments. Objectives: The present systematic review is conducted to assess the effectiveness of inhaled budesonide on hospitalization and ...
Akefeh Ahmadi Afshar, Maryam Rahmati, Azam Maleki, Kourosh Kamali   +3 more
doaj   +1 more source

Evolving targets for heart failure: the journey so far

Global Cardiology, 2023
The treatment of heart failure has included vasodilators, positive inotropes and most successfully neurohormonal blockade. Recent research has looked at metabolic and immune modulatory approaches, and implantable, mainly electrical devices.
Giuseppe M.C. Rosano, Jerneja Farkas
doaj   +1 more source

Analysis of the characteristics and the degree of pragmatism exhibited by pragmatic-labelled trials of antineoplastic treatments

BMC Medical Research Methodology, 2023
Background Pragmatic clinical trials (PCTs) are designed to reflect how an investigational treatment would be applied in clinical practice. As such, unlike their explanatory counterparts, they measure therapeutic effectiveness and are capable of ...
Robbe Saesen, Kevin Depreytere, Karyna Krupianskaya, Joël Langeweg, Julie Verheecke, Denis Lacombe, Isabelle Huys   +6 more
doaj   +1 more source

Commentary of "Placebo Studies in Developing Countries: Ethical, but not Ideal"

Voices in Bioethics, 2014
In his piece, Scott is against the notion that using placebos as controls (when there is an existing treatment method) in randomized controlled trials (RCTs) is never ethical.
Marilyn Eshikena
doaj   +1 more source

TRUST Study: Participation in Randomized Controlled Trials and Subsequent Adherence to Visiting Medical Institutions and Taking Medications in Patients with Cardiovascular Diseases. Part II. Assessment of the Quality of Therapy

Рациональная фармакотерапия в кардиологии, 2020
Aim. Based on the data of the TRUST study (Influence of Participation in Randomized Controlled Trials on adheRence to Medicines' Intake and regUlar viSits to the docTor) to assess the quality of drug therapy and patients' awareness of achieving target ...
N. O. Vasyukova, N. P. Kutishenko, Yu. V. Lukina, O. I. Zvonareva, S. Yu. Martsevich   +4 more
doaj   +1 more source