Results 271 to 280 of about 21,585,462 (349)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Adaptive clinical trials in surgery: A scoping review of methodological and reporting quality. [PDF]

PLoS One
Staibano P, Oulousian E, McKechnie T, Thabane A, Luo S, Gupta MK, Zhang H, Pasternak JD, Au M, Parpia S, Young JEMT, Bhandari M.   +11 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Assessment of Harms Reporting Quality in Randomized Controlled Trials of Aesthetic Rhinoplasty: A Systematic Review. [PDF]

Aesthet Surg J Open Forum
Behroozian T, Ripan V, Kim P, Yuan M, Gallo L, Ulhman K, McRae M, Podolsky D, Ahmad J.   +8 more
europepmc   +1 more source

The reporting quality of randomized controlled trials in pharmacotherapy for pituitary adenomas. [PDF]

Medicine (Baltimore)
Yan H, Wang D, Zhao Y, Miao J, Wang Z.
europepmc   +1 more source

Reporting Quality of AI Intervention in Randomized Controlled Trials in Primary Care: Systematic Review and Meta-Epidemiological Study.

J Med Internet Res
Zhong J, Zhu T, Huang Y.
europepmc   +1 more source

Reporting quality of animal research in journals that published the ARRIVE 1.0 or ARRIVE 2.0 guidelines: a cross-sectional analysis of 943 studies. [PDF]

Cardiovasc Diagn Ther
Lin Y, Yang F, Shang B, Speich JE, Wan YY, Hashida H, Braun T, Sadoughi A, Puehler T, Lue TF, Zhang K.   +10 more
europepmc   +1 more source

CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trials. [PDF]

EClinicalMedicine
Rekowski J, Guo C, Solovyeva O, Dimairo M, Rouhifard M, Patel D, Alger E, Ashby D, Berlin J, Boix O, Calvert M, Chan AW, Coschi CH, de Bono J, Evans TRJ, Garrett-Mayer E, Golub RM, Hayward KS, Hopewell S, Isaacs JD, Ivy SP, Jaki T, Kholmanskikh O, Kightley A, Lee S, Liu R, Maia I, Mander A, Marshall LV, Matcham J, Peck R, Rantell KR, Richards DP, Seymour L, Tanaka Y, Ursino M, Weir CJ, Yap C.   +37 more
europepmc   +1 more source

Reporting quality and risk of bias of randomized controlled trials of Chinese herbal medicine for multiple sclerosis. [PDF]

Front Immunol
Wu JY, Yang JL, Hu JL, Xu S, Zhang XJ, Qian SY, Chen ML, Ali MA, Zhang J, Zha Z, Zheng GQ.   +10 more
europepmc   +1 more source