Results 81 to 90 of about 1,157,786 (311)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality

Objective Using genetically-modified animals to model neurodevelopmental conditions (NDCs) helps better our understanding of biology underlying these conditions.
Malcolm Robert Macleod, Gillian Currie, Peter Kind, Emily Sena, Emma Wilson   +4 more
core   +1 more source

Pilot studies: Are they appropriately reported?

Perspectives in Clinical Research, 2015
Introduction: Pilot studies play a pivotal role in deciding whether a main study can be undertaken thereby helping in appropriate framing of time, cost and study methods.
S Kannan, S Gowri
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Does Regulatory Environment affect Earnings Management in Transitional Economies? An Empirical Examination of the Financial Reporting Quality of Cross-Listed Firms of China and Hong Kong [PDF]

, 2015
This paper provides evidence on the impact of regulatory environment on financial reporting quality of transitional economies. This study compares the financial reporting quality of Hong Kong firms which are cross-listed in mainland China with those of ...
Omoteso, Kamil, Yu, Yi, Matthias Nnadi, Nnadi, Matthias, Yi Yu, Kamil Omoteso   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Financial reporting quality of ESG firms listed in China.

, 2023
Given the growing importance of environmental protection in China, this study investigated the determinants of the financial reporting quality of environmental, social and governance (ESG) firms listed in China.
Mengqian Wu, Indra Abeysekera
core   +1 more source

Reporting Guidelines for Music-based Interventions checklist: explanation and elaboration guide

Frontiers in Psychology
BackgroundDetailed intervention reporting is essential to interpretation, replication, and eventual translation of Music-based Interventions (MBIs) into practice.
Sheri L. Robb, K. Maya Story, Elizabeth Harman, Debra S. Burns, Joke Bradt, Emmeline Edwards, Tasha L. Golden, Christian Gold, Christian Gold, Christian Gold, John R. Iversen, Assal Habibi, Julene K. Johnson, Miriam Lense, Susan M. Perkins, Stacey Springs   +15 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Workplace Disruptions Impact on Financial Reporting Quality

, 2022
This study provides evidence that workplace disruptions impact financial reporting quality. I use the novel setting of company headquarter relocation to study workplace disruptions.
Sigler, Jake
core