Results 131 to 140 of about 25,080,468 (342)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A Detailed Analysis of the Productivity Performance of Mining in Canada [PDF]
In recent years, the productivity performance of mining in Canada has been very poor. Based on official real GDP and labour input estimates from Statistics Canada, labour productivity in mining fell by 2.21 per cent per year between the 2000 cyclical ...
Andrew Sharpe, Celeste Bradley
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Impending ice age of assisted reproductive technology
F&S Reports, 2020 Pietro Bortoletto, M.D.
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Celebrating our one-year anniversary
Cell Reports SustainabilityMelissa Plail, Lu Liu, Richard Thompson
doaj +1 more source
Reading beyond the Classroom: The Effects of Extensive Reading at USTA, Tunja
HOW, 2009 The purpose of this study was to observe and describe the effects of applying extensive reading to a group of fifth level English students at Universidad Santo Tomás de Aquino and be accepted into the English Program.
Nery Yolanda Ruíz de Guerrero +1 more
doaj
Economic Activity of the On-Reserve Aboriginal Identity Population in Canada: Gross Domestic Product Estimates for Indian Reserves, 2000 and 2005 [PDF]
This report develops estimates of Gross Domestic Product (GDP) for reserves in Canada by estimating total earnings for reserves and multiplying these results by the national share of total earnings in income-based GDP.
Elspeth Hazell +1 more
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