Results 41 to 50 of about 355,869 (305)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Media representation of tobacco control in China: A comparative analysis of agenda-setting across different policy contexts during 2017–2022

Tobacco Induced Diseases
Introduction While media play a crucial role in tobacco control policy advancement, little is known about how different policy contexts shape media coverage of tobacco control, particularly in China’s unique political and administrative systems.
Yu Chen, Yujiang Cai, Xinrui Yang, Xinyao Yu, Rui Zhang, Heng Zhang, Jing Xu, Kin-Sun Chan   +7 more
doaj   +1 more source

The Radical Right versus the Media: from Media Critique to Claims of (Mis)Representation

Politics and Governance, 2019
Criticizing mainstream media for their ‘lies’ or ‘fake news’ has become a common political practice on the radical right. Further empirical research is needed to better understand the intricacies of these attacks on media, in particular for the way they ...
Louise Knops, Benjamin De Cleen
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

News production on the arrival of migrants by sea to Spanish coasts: the case of the Balearic Islands

Estudios sobre el Mensaje Periodístico
This article explores the communicative strategies of journalists and institutional offices on the arrival of migrants by sea to Spanish coasts through a case study: the Balearic Islands.
María Ruiz Aranguren
doaj   +1 more source

Representation and beyond; Female victims in Post-Suharto media

Wacana: Journal of the Humanities of Indonesia, 2012
This study analyses representations of female victims in post-Suharto media. In so doing, it underlines the import of the fall of the New Order regime and the concurrent opening up of the media world in Indonesia.
Wiwik Sushartami
doaj   +1 more source

Neutrino propagator in media: spin properties and spectral representation [PDF]

EPJ Web of Conferences, 2019
We have found that in case of propagation of neutrino in the moving matter or external magnetic field there is a fixed 4-axis of polarization, which corresponds to spin projectors commute with a propagator.
Kaloshin Alexander, Voronin Dmitry
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Evolving Landscape of Spanish Language Representation in U.S. Media: From Overt to Covert Discrimination

Languages
Despite the continuously expanding presence of Spanish-speaking communities in the United States, media representation of the Spanish language and that of its speakers has remained relatively scarce.
Grace A. Parker, Maia Botek, Diego Pascual y Cabo   +2 more
doaj   +1 more source