Results 51 to 60 of about 371,688 (306)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Evolving Landscape of Spanish Language Representation in U.S. Media: From Overt to Covert Discrimination

open access: yesLanguages
Despite the continuously expanding presence of Spanish-speaking communities in the United States, media representation of the Spanish language and that of its speakers has remained relatively scarce.
Grace A. Parker   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Women Voices in Inter-Party Debates during the 2021 Ethiopian General Elections

open access: yesAfrican Journal of Political Science
In Ethiopia, multiparty elections are being organised every five years.  For the 2021 general election, 47 parties were registered and more than 9,300 candidates ran for seats, of which, 1, 982 were women candidates. This study explored women candidates’
Seblewongiel Ayenalem Kidanie
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Imagens de mulher: representações do envelhecimento feminino nos media brasileiros

open access: yesComunicação e Sociedade, 2012
This text is part of a more extensive project I am currently working on entitled “Representation of the others: How the Media looks at diversity” which intends to investigate, through analysis of different media productions, contents related to various ...
Maria Luisa Mendonça
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Rethinking (and Retheorizing) Transgender Media Representation: A Roundtable Discussion

open access: yesInternational Journal of Communication, 2020
This roundtable began as the first panel of the International Communication Association dedicated exclusively to transgender studies. The articles of the panel investigated various domains of mediated representation, from television to newspapers to ...
Thomas J Billard   +5 more
doaj  

Transforming Representation: Jacques Derrida and the End of Christianity

open access: yesOpen Theology, 2019
The central question of this paper revolves around the problem of representation. Following Jacques Derrida and his critique of representation, this paper will interconnect two, at first sight distinct, topics: Christianity and the world of media.
Koci Martin
doaj   +1 more source

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