Results 51 to 60 of about 17,391 (259)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Reseña del Libro de S. Tormey "The End of Representative Politics"

open access: yesRecerca: Revista de Pensament i Anàlisi, 2017
Simon Tormey’s book, The End of Representative Politics, draws on his work on representation from the last decade as well as on a case study of the tumultuous, but exciting, Spanish politics of recent years. Tormey is interested in a new form of politics
Lasse Thomassen
doaj  

Barbarossa − Bar(bar)ossa − Barbossa: The permanence of the Black Legend as a discourse of otherness

open access: yesChasqui, 2018
This article explores contemporary cultural appropriations of the Black Legend, a 16th and 17th century narrative used as a propagandistic strategy addressed to criticize Spain’s imperial mission in America.
Salvador Leetoy, Miguel Vázquez Liñán
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Muslim Women and the Politics of Representation

open access: yesAmerican Journal of Islam and Society, 2002
This paper examines the politics of knowledge production as it relates to Muslim women in western literar y traditions and contemporary feminist writing, with a view to understanding the political, ideological, and economic mediations that have ...
Jasmin Zine
doaj   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

VI Zverev International Conference at RSUH “Collective Memory: Power of the Past in Socio-Cultural Life in the USA” [PDF]

open access: yesЛитература двух Америк, 2019
The review outlines the major topics of the conference on the American Studies held by the Russian State University for the Humanities in May 2019.
Victoria I. Zhuravleva   +1 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

The Impact of Electoral Gender Quotas on Women’s Political Participation in Bosnia and Herzegovina

open access: yesPolitics in Central Europe, 2023
Although representing half of the world population, women remain largely excluded from political power and government structures. Various strategies have been introduced to increase women’s political representation, including electoral gender quotas ...
Merdanović Ajla Van Heel   +1 more
doaj   +1 more source

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