Results 31 to 40 of about 1,680 (247)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Boundary maps and maximal representations on infinite dimensional Hermitian symmetric spaces

open access: yes, 2018
We define a Toledo number for actions of surface groups and complex hyper-bolic lattices on infinite dimensional Hermitian symmetric spaces, which allows us to define maximal representations.
Duchesne, Bruno   +2 more
core   +2 more sources

A relationship between rational and multi-soliton solutions of the BKP hierarchy [PDF]

open access: yes, 2005
We consider a special class of solutions of the BKP hierarchy which we call $\tau$-functions of hypergeometric type. These are series in Schur $Q$-functions over partitions, with coefficients parameterised by a function of one variable $\xi$, where the ...
Orlov, A.Y., Nimmo, J.J.C.
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Relations between unitary representations of diffeomorphism groups and those of the infinite symmetric group or of related permutation groups [PDF]

open access: yesKyoto Journal of Mathematics, 1997
The authors study the interrelations between unitary representations of two kinds of groups. One of them is the group \(G=\text{Diff}_0 (M)\) of diffeomorphisms with compact support on a manifold of class \(C^{(n)}\), \(1\leq n\leq\infty\), and the others are certain permutation groups \(S\) contained in the group \(\widetilde \Sigma_\infty\) of all ...
Hirai, Takeshi, Shimomura, Hiroaki
openaire   +2 more sources

Stepwise Square Integrable Representations: The Concept and Some Consequences [PDF]

open access: yes, 2016
There are some new developments on Plancherel formula and growth of matrix coefficients for unitary representations of nilpotent Lie groups. These have several consequences for the geometry of weakly symmetric spaces and analysis on parabolic subgroups ...
Joseph A. Wolf, Wolf, Joseph A
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Admissible representations and characters of the affine superalgebras osp(l,2) and ŝl(2|l) [PDF]

open access: yes, 1998
In this thesis we compute characters and supercharacters of irreducible admissible representations for the two affine superalgebras osp(l,2;C) and l(2|l;C).The work on osp(l, 2; C) includes a derivation of the embedding diagram.
Hayes, Michael Robert
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

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