Results 121 to 130 of about 73,999 (368)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

CARTOGRAFIAS GEOGRÁFICAS: O QUE PODE UM MAPA...

open access: yesRevista Geographia, 2018
Resumo: Pensar o mapa é pensá-lo como o agenciamento de forças, de linhas/corpos que se afetam e apontam para sentidos de localização e orientação espacial.
Djeovani Roos   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

TEMPORALITY OF THE NARRATIVE OF CONTEMPORARY TRAVEL LITERATURE (Based on Cees Nooteboom’s work) [PDF]

open access: yesAlfred Nobel University Journal of Philology
The article examines the temporality of narrative in the discourse of contemporary travel literature in the context of socio-cultural dynamics associated with the digitalization of life forms, socio-cultural interactions and new models of comprehension,
Olena I. Kretova, Pavlo V. Kretov
doaj   +1 more source

Mixed Reality Architecture: Concept, Construction, Use [PDF]

open access: yes, 2003
Mixed Reality Architecture (MRA) dynamically links and overlays physical and virtual spaces. This paper investigates the topology of and the relationships between the components of MRA.
Benford, S   +3 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Examining Elements of Middle Eastern Dystopia: A Comparative Study of Vaght-e Taghsir and Frankenstein in Baghdad [PDF]

open access: yesتاریخ ادبیات
IntroductionThe term “dystopia” was coined in 1868 in reference to authoritarian societies, and it often relates to totalitarian regimes (Vieira, 2010: 5&16; Baccolini & Moylan, 2013: 4-7). It was first used in English literature in 1747, albeit with the
Zein Alabedeen Asaad, Mohammad Ragheb
doaj   +1 more source

Design synthesis and shape generation [PDF]

open access: yes, 2009
If we are to capitalise on the potential that a design approach might bring to innovation in business and society, we need to build a better understanding of the evolving skill-sets that designers will need and the contexts within which design might ...
AHRC (Funder)   +11 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

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