Results 71 to 80 of about 67,579 (318)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

London in space and time: Peter Ackroyd and Will Self [PDF]

, 2013
Copyright @ 2013 the author. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License.This paper explores the treatment of London by two authors who are profoundly influenced by the concept of the ...
Green, A
core  

'Sexercise': Working out heterosexuality in Jane Fonda’s fitness books [PDF]

, 2011
This is an Author's Accepted Manuscript of an article published in Leisure Studies, 30(2), 237 - 255, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/02614367.2010.523837.This paper explores the connection ...
Aitchison C., Altheide D., Ashburner L., Atkinson P., Bell B., Berg B., Best A., Binnie J., Blunt A., Broad K., Browne K., Caudwell J., Caudwell J., Clift S., Cole C., Conant J., Davidson P., DeLyser F., DeLyser F., DePauw K., Dworkin S., Featherstone M., Fitzpatrick E., Fonda J., Fonda J., Fonda J., Fonda J., Gill R., Gratton C., Hargreaves J., Hargreaves J., Hubbard P., Ingham A., Ingraham C., Jackson S., Jackson S., Jette S., Johnston L., King S., Kramarae C., Longhurst R., Longhurst R., Louise Mansfield, MacNeill M., Markula P., Massey D., Massey D., McCrone K., McDowell L., McKay H., Melillo W., Melillo W., Nast H., Oliver M., Pilcher J., Pronger B., Richardson D., Rose G., Rose G., Ryan C., Schell L., Shilling C., Smith Maguire J., Stack P., Sykes H., van Dijk T.   +65 more
core   +1 more source

Spatial Representation: Maps of Fragmented Space [PDF]

Current Biology, 2015
Grid cells in medial entorhinal cortex are thought to act as a neural metric for spatial navigation. A new study has examined the ability of grid cells to use self-motion cues to form a global map across fragmented spaces.
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Social and novel contexts modify hippocampal CA2 representations of space

Nature Communications, 2016
The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown ...
G. M. Alexander, S. Farris, Jason R. Pirone, C. Zheng, L. Colgin, S. Dudek   +5 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Unsupervised spatially embedded deep representation of spatial transcriptomics

Genome Medicine
AbstractOptimal integration of transcriptomics data and associated spatial information is essential towards fully exploiting spatial transcriptomics to dissect tissue heterogeneity and map out inter-cellular communications. We present SEDR, which uses a deep autoencoder coupled with a masked self-supervised learning mechanism to construct a low ...
Hang Xu, Huazhu Fu, Yahui Long, Kok Siong Ang, Raman Sethi, Kelvin Chong, Mengwei Li, Rom Uddamvathanak, Hong Kai Lee, Jingjing Ling, Ao Chen, Ling Shao, Longqi Liu, Jinmiao Chen   +13 more
openaire   +3 more sources

Behavioral and Neural Representations of Spatial Directions across Words, Schemas, and Images

Journal of Neuroscience, 2017
Modern spatial navigation requires fluency with multiple representational formats, including visual scenes, signs, and words. These formats convey different information. Visual scenes are rich and specific but contain extraneous details.
Steven M. Weisberg, Steven A. Marchette, A. Chatterjee   +2 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source