Results 71 to 80 of about 569 (262)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Navigating the Liminal Spaces: Intertextual Journeys and Monomyth Structures in Fowles’ The Magus [PDF]
Alfred Nobel University Journal of PhilologyThe aim of the article is to identify the distinctive features of mythological allusions as a means of constructing liminal spaces and to identify the liminal states of the main character in John Fowles’s novel The Magus, with particular attention to ...
Nataliia Kravchenko , Nina Nikolska
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
CARTOGRAFIAS GEOGRÁFICAS: O QUE PODE UM MAPA...
Revista Geographia, 2018 Resumo: Pensar o mapa é pensá-lo como o agenciamento de forças, de linhas/corpos que se afetam e apontam para sentidos de localização e orientação espacial.
Djeovani Roos +1 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Spatial representation for pragmatic navigation [PDF]
, 1997 This paper focuses upon features of two-dimensional space that facilitate and/or obstruct travel through it. Three kinds of facilitators and four kinds of obstructers are identified. For each one, learning algorithms and navigational applications are proposed. The program described here simulates a robot that learns such features as it encounters them,
openaire +1 more source
Representation Learning for Spatial Graphs
CoRR, 2018 4 pages, 1 figure ...
Zheng Wang 0046 +3 more
openaire +2 more sources
TEMPORALITY OF THE NARRATIVE OF CONTEMPORARY TRAVEL LITERATURE (Based on Cees Nooteboom’s work) [PDF]
Alfred Nobel University Journal of PhilologyThe article examines the temporality of narrative in the discourse of contemporary travel literature in the context of socio-cultural dynamics associated with the digitalization of life forms, socio-cultural interactions and new models of comprehension,
Olena I. Kretova, Pavlo V. Kretov
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
ReligionsDuring a 2-year period, the depictions of religious figures and their interactions with secular individuals in urban daily life became an integral feature of Turkish soap operas that gained popularity in the world after the 1990s.
Şeyma Ayyildiz
doaj +1 more source