Results 71 to 80 of about 569 (261)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Navigating the Liminal Spaces: Intertextual Journeys and Monomyth Structures in Fowles’ The Magus [PDF]
Alfred Nobel University Journal of PhilologyThe aim of the article is to identify the distinctive features of mythological allusions as a means of constructing liminal spaces and to identify the liminal states of the main character in John Fowles’s novel The Magus, with particular attention to ...
Nataliia Kravchenko , Nina Nikolska
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CARTOGRAFIAS GEOGRÁFICAS: O QUE PODE UM MAPA...
Revista Geographia, 2018 Resumo: Pensar o mapa é pensá-lo como o agenciamento de forças, de linhas/corpos que se afetam e apontam para sentidos de localização e orientação espacial.
Djeovani Roos +1 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
ReligionsDuring a 2-year period, the depictions of religious figures and their interactions with secular individuals in urban daily life became an integral feature of Turkish soap operas that gained popularity in the world after the 1990s.
Şeyma Ayyildiz
doaj +1 more source
TEMPORALITY OF THE NARRATIVE OF CONTEMPORARY TRAVEL LITERATURE (Based on Cees Nooteboom’s work) [PDF]
Alfred Nobel University Journal of PhilologyThe article examines the temporality of narrative in the discourse of contemporary travel literature in the context of socio-cultural dynamics associated with the digitalization of life forms, socio-cultural interactions and new models of comprehension,
Olena I. Kretova, Pavlo V. Kretov
doaj +1 more source
Spatial representation for pragmatic navigation [PDF]
, 1997 This paper focuses upon features of two-dimensional space that facilitate and/or obstruct travel through it. Three kinds of facilitators and four kinds of obstructers are identified. For each one, learning algorithms and navigational applications are proposed. The program described here simulates a robot that learns such features as it encounters them,
openaire +1 more source
Representation Learning for Spatial Graphs
CoRR, 2018 4 pages, 1 figure ...
Zheng Wang 0046 +3 more
openaire +2 more sources