Results 111 to 120 of about 580,630 (249)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Twenty-first-century compatible co2 emissions and airborne fraction simulated by cmip5 earth system models under four representative concentration pathways

, 2013
The carbon cycle is a crucial Earth system component affecting climate and atmospheric composition. The response of natural carbon uptake to CO2 and climate change will determine anthropogenic emissions compatible with a target CO2 pathway.
C Roelandt (21845645), P Friedlingstein (7787252), E Shevliakova (21845633), M Kawamiya (21845639), CH Reick (21845642), K Lindsay (16092668), J Tjiputra (16115597), C Jones (7733585), V Arora (13711960), T Hajima (21845636), E Robertson (13734823), S Liddicoat (16380273), J Segschneider (16164482), L Bopp (15978953), E Kato (16164455), V Brovkin (9935750)   +15 more
core  

Quantifying the Ancillary Benefits of the Representative Concentration Pathways on Air Quality in Europe [PDF]

, 2015
This paper presents estimates of the economic benefit of air quality improvements in Europe that occur as a side effect of GHG emission reductions.
Melichar, Jan, Šcasný, Milan, Massetti, Emanuele, Carrara, Samuel   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Consequences of 1.5 °C and 2 °C global warming levels for temperature and precipitation changes over Central Africa

Environmental Research Letters, 2018
Discriminating climate impacts between 1.5 °C and 2 °C warming levels is particularly important for Central Africa, a vulnerable region where multiple biophysical, political, and socioeconomic stresses interact to constrain the region’s adaptive capacity.
Wilfried Pokam Mba, Georges-Noel T Longandjo, Wilfran Moufouma-Okia, Jean-Pierre Bell, Rachel James, Derbetini A Vondou, Andreas Haensler, Thierry C Fotso-Nguemo, Guy Merlin Guenang, Angennes Lucie Djiotang Tchotchou, Pierre H Kamsu-Tamo, Ridick R Takong, Grigory Nikulin, Christopher J Lennard, Alessandro Dosio   +14 more
doaj   +1 more source

Representative Agricultural Pathways and Scenarios for Regional Integrated Assessment of Climate Change Impacts, Vulnerability, and Adaptation

, 2015
The global change research community has recognized that new pathway and scenario concepts are needed to implement impact and vulnerability assessment where precise prediction is not possible, and also that these scenarios need to be logically consistent
Cynthia Rosenzweig, Rosenzweig, Cynthia, Rasnayaka, Herath, Ruane, Alexander C., Antle, J M, Mulwa, R, Rosenzweig, C, Vervoort, J, Hathie, Ibrahima, Valdivia, R O, Nhemachena, C, Joost Vervoort, Mulwa, Richard, John M. Antle, Nhemachena, Charles, Ponnusamy, Paramasivam, Charles Nhemachena, Ruane, A C, Ponnusamy, P, Singh, H, Hathie, I, Roberto O. Valdivia, Ibrahima Hathie, Singh, Harbir, Vervoort, Joost, Richard Mulwa, Alexander C. Ruane, Harbir Singh, Tui, Sabine Homann-Kee, Valdivia, Roberto O., Ashfaq, M, Rasnayaka, H, Herath Rasnayaka, Ashfaq, Muhammad, Sabine Homann-Kee Tui, Muhammad Ashfaq, Antle, John M., Hathie, S H K, Paramasivam Ponnusamy   +38 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Assessment of the best representative concentration pathways (RCPs) for northern Malaysia [PDF]

, 2019
Consequence from the climate change in Malaysia had leads to flood disaster in Perlis that happened in year 2010 that involved 50 000 victims need to evacuate from their house to temporary settlement areas besides caused death of 6 victims.
Fatin Nabila, Abllah
core  

Global Climate Models (GCMs) used to obtain future climate predictions representative of 2050.

, 2017
All GCMs were calculated for two different Representative Concentration Pathways (RCPs), namely RCP4.5 and RCP8.5, totalling to 18 (9 x 2) different future climate predictions.
Mario Soliño (525109), María Jesús Serra-Varela (3296874), Julián Gonzalo (3743335), Rosa Raposo (673019), Delphine Grivet (3258225), Javier Pórtoles (3743332), Ricardo Alía (478896)   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source