Results 101 to 110 of about 577,757 (250)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Quantifying the influence of climate change on streamflow of Rietspruit sub-basin, South Africa
Journal of Water and Climate ChangeThis study integrated climate projections from five global climate models (GCMs) into the soil and water assessment tool to evaluate the potential impact of climate alterations on the Rietspruit River sub-basin under two representative concentration ...
Vincent Dzulani Banda +3 more
doaj +1 more source
Inventories and scenarios of nitrous oxide emissions
Environmental Research Letters, 2014 Effective mitigation for N _2 O emissions, now the third most important anthropogenic greenhouse gas and the largest remaining anthropogenic source of stratospheric ozone depleting substances, requires understanding of the sources and how they may ...
Eric A Davidson, David Kanter
doaj +1 more source
Effects of future climate on suitability of major crops in Eastern Kansas River Basin [PDF]
Journal of Water and Land DevelopmentClimate change significantly threatens food security and the agricultural economy, particularly under rainfed conditions. This study uses the Decision Support System for Agrotechnology Transfer (DSSAT) crop simulation model to evaluate the future ...
Rintu Sen +4 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Revista Brasileira de Ciências Ambientais, 2022 This work aimed to analyze the average temperature and rainfall in the Southern and Steppe regions of the State of Rio Grande do Sul, Brazil, obtained by three global climate models regionalized by the Eta model (CANESM2, HADGEM2-ES and MIROC5) for the ...
Iulli Pitone Cardoso +4 more
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source