Results 101 to 110 of about 580,630 (249)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Quantifying the influence of climate change on streamflow of Rietspruit sub-basin, South Africa

Journal of Water and Climate Change
This study integrated climate projections from five global climate models (GCMs) into the soil and water assessment tool to evaluate the potential impact of climate alterations on the Rietspruit River sub-basin under two representative concentration ...
Vincent Dzulani Banda, Rimuka Bloodless Dzwairo, Sudhir Kumar Singh, Thokozani Kanyerere   +3 more
doaj   +1 more source

Inventories and scenarios of nitrous oxide emissions

Environmental Research Letters, 2014
Effective mitigation for N _2 O emissions, now the third most important anthropogenic greenhouse gas and the largest remaining anthropogenic source of stratospheric ozone depleting substances, requires understanding of the sources and how they may ...
Eric A Davidson, David Kanter
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Analysis of average annual temperatures and rainfall in southern region of the state of Rio Grande do Sul, Brazil

Revista Brasileira de Ciências Ambientais, 2022
This work aimed to analyze the average temperature and rainfall in the Southern and Steppe regions of the State of Rio Grande do Sul, Brazil, obtained by three global climate models regionalized by the Eta model (CANESM2, HADGEM2-ES and MIROC5) for the ...
Iulli Pitone Cardoso, Tirzah Moreira Siqueira, Luis Carlos Timm, Aryane Araujo Rodrigues, André Becker Nunes   +4 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Past, present and future climate trends under varied representative concentration pathways for a sub-humid region in Uganda

, 2019
21 p. : col. ;Long-term trend analysis at local scale for rainfall and temperature is critical for detecting climate change patterns. This study analysed historical (1980–2009), near future (2010–2039), mid- (1940–2069) and end-century (2070–2099 ...
Makooma, Moses Tenywa, Siya, Aggrey, Egeru, Anthony, Nampijja, Josephine, Barasa, Bernard, Majaliwa, Mwanjalolo G. J.   +5 more
core   +2 more sources

Projecting the Future Bioclimatic Environment of Bratislava: A UTCI-Based Analysis Under Representative Concentration Pathway Scenarios

Slovak Journal of Civil Engineering
This article deals with a future projection of the bioclimatic environment in Bratislava, Slovakia, under ongoing climate change. Using Meteonorm-generated climate data of up to 2100, this research paper presents calculations of the Universal Thermal ...
Hakszer Tomáš, Hanuliak Peter
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source