Results 81 to 90 of about 580,630 (249)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Journal of AgrometeorologyClimate change represents a challenge for agricultural production in Mexico, so this research determined the productive potential in the Lerma-Toluca Basin under historical (1991-2020) and future (2050 and 2070) scenarios with RCP 4.5 and 8.5.
J. E. REYES-ANDRADE +2 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Climate change-induced shifts in landslide susceptibility in São Sebastião (southeastern Brazil)
Natural Hazards ResearchLandslides are a pressing natural hazard, particularly in regions prone to extreme weather events, and their frequency is expected to rise due to climate change.
Enner Alcântara +4 more
doaj +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Scientific ReportsRising global temperatures and frequent extreme heat waves have caused changes in people’s energy consumption patterns, leading to a significant impact on electricity consumption.
Bin Yang, Bin Song, Yadegar Abdi
doaj +1 more source
Early retirement of power plants in climate mitigation scenarios
Environmental Research Letters, 2020 International efforts to avoid dangerous climate change aim for large and rapid reductions of fossil fuel CO _2 emissions worldwide, including nearly complete decarbonization of the electric power sector.
Robert Fofrich +9 more
doaj +1 more source
, 2022 Development of local climate is important for climate hazard assessment. Cameron Highlands was chosen as study area (longitude from 101°21’ to 101°30’ and latitude from 4°19’ to 4°37’) for climate downscaling.
Kok Weng Tan, Jin Min Pang
core +1 more source