Results 61 to 70 of about 577,757 (250)

Multi-model cropping seasons projections over pakistan under representative concentration pathways [PDF]

Modeling Earth Systems and Environment, 2015
This study examines the changes in soil moisture derived from 24 global climate model (GCM) simulations of Coupled Model Intercomparison Project phase 5 (CMIP5) over the cropping seasons (Kharif and Rabi) of Pakistan from 2021 to 2050. The comparison of historical run with reanalysis global land data assimilation system for the period 1971–2000 have ...
Maida Zahid, Waheed Iqbal
openaire   +1 more source

Future Water Availability Under Representative Concentration Pathways Scenario in Baro Basin, Ethiopia [PDF]

Journal of Water Resources and Ocean Science, 2021
The objective in this study was to assess future water availability in the upper part of the Baro basin in Southwest Ethiopia through the Representative Concentration Pathway (RCP 4.5) scenario. HBV-96 rainfall-runoff model was calibrated and validated for historical records of streamflow.
openaire   +1 more source

Climate Change Impacts on the Energy System of a Climate-Vulnerable Mediterranean Country (Greece)

Atmosphere
Climate change is expected to significantly affect countries in Southern Europe and the Mediterranean Basin, causing higher-than-average temperature increases, considerable reductions in rainfall and water runoff, and extreme events such as heatwaves ...
Elena Georgopoulou, Sevastianos Mirasgedis, Yannis Sarafidis, Christos Giannakopoulos, Konstantinos V. Varotsos, Nikos Gakis   +5 more
doaj   +1 more source

Spatio-temporal analysis of temperature projections based on representative concentration pathways for Satluj River Basin, India

Cogent Engineering, 2021
A spatio-temporal analysis of representative concentration pathways (RCPs)-based projections of surface air temperatures under different combinations of global circulation models (GCMs) and RCPs for Satluj River Basin has been presented.
Mukesh Kumar Gupta, Mohammed Sharif
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nationwide projections of heat- and cold-related mortality impacts under various climate change and population development scenarios in Switzerland

Environmental Research Letters, 2023
Climate change and progressive population development (i.e., ageing and changes in population size) are altering the temporal patterns of temperature-related mortality in Switzerland.
Evan de Schrijver, Sidharth Sivaraj, Christoph C Raible, Oscar H Franco, Kai Chen, Ana M Vicedo-Cabrera   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source