Results 51 to 60 of about 580,630 (249)

Projected pH reductions by 2100 might put deep North Atlantic biodiversity at risk [PDF]

, 2014
This study aims to evaluate the potential for impacts of ocean acidification on North Atlantic deep-sea ecosystems in response to IPCC AR5 Representative Concentration Pathways (RCPs).
Gehlen, Marion, Dunne, John P., Roth, Raphael, Dunne, J.P., J. C. Orr, S. C. Doney, Orr, J., Jones, Daniel O.B., Tjiputra, Jerry, L. Bopp, M. Gehlen, Doney, S., Roth, R., Orr, J.C., Joos, F., T. Roy, Orr, J. C., Resplandy, Laure, J. Barry, Barry, James P., J. P. Dunne, Heinze, Christoph, Heinze, C., Doney, Scott C., L. Resplandy, Dunne, J., R. Roth, Jones, D.O.B., Doney, S.C., Resplandy, L., Bopp, L., Jones, Daniel O. B., Séférian, R., Segschneider, J., R. Séférian, Dunne, J. P., Doney, S. C., Joos, Fortunat, Barry, J., Bopp, Laurent, Gehlen, M., Orr, James, Segschneider, Joachim, F. Joos, Jones, D. O. B., Tjiputra, J., Séférian, Roland, Roy, Tilla, D. O. B. Jones, C. Heinze, J. Tjiputra, J. Segschneider, Roy, T., Orr, James C., Jones, D.   +54 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Future Projection of Droughts over South Korea Using Representative Concentration Pathways (RCPs)

Terrestrial, Atmospheric and Oceanic Sciences, 2014
The Standardized Precipitation Index (SPI), a method widely used to analyze droughts related to climate change, does not consider variables related to temperature and is limited because it cannot consider changes in hydrological balance, such as ...
Byung Sik Kim, In Hyeok Park, Sung Ryong Ha   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Future changes in extreme heatwaves in terms of intensity and duration over the CORDEX-East Asia Phase Two domain using multi-GCM and multi-RCM chains

Environmental Research Letters, 2023
An extreme heatwave, in terms of intensity and duration, is projected to occur at the end of the 21st century (2071–2100) over the whole of East Asia.
Young-Hyun Kim, Joong-Bae Ahn, Myoung-Seok Suh, Dong-Hyun Cha, Eun-Chul Chang, Seung-Ki Min, Young-Hwa Byun, Jin-Uk Kim   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Climate Change Impacts on the Energy System of a Climate-Vulnerable Mediterranean Country (Greece)

Atmosphere
Climate change is expected to significantly affect countries in Southern Europe and the Mediterranean Basin, causing higher-than-average temperature increases, considerable reductions in rainfall and water runoff, and extreme events such as heatwaves ...
Elena Georgopoulou, Sevastianos Mirasgedis, Yannis Sarafidis, Christos Giannakopoulos, Konstantinos V. Varotsos, Nikos Gakis   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Replication Data for: A simulated roadmap of hydrogen technology contribution to climate change mitigation based on Representative Concentration Pathways considerations.

Hydrogen as fuel has been a promising technology towards climate change mitigation efforts. Having this said, this work analyses the contribution of the technology to future global environmental goals.
Maria Diamantaki, Diotima Karanikolou-Karra, George Fragogiannis, Lazarou, Stavros, Lambros Ekonomou, Sofoklis Makridis   +5 more
core   +2 more sources

Nationwide projections of heat- and cold-related mortality impacts under various climate change and population development scenarios in Switzerland

Environmental Research Letters, 2023
Climate change and progressive population development (i.e., ageing and changes in population size) are altering the temporal patterns of temperature-related mortality in Switzerland.
Evan de Schrijver, Sidharth Sivaraj, Christoph C Raible, Oscar H Franco, Kai Chen, Ana M Vicedo-Cabrera   +5 more
doaj   +1 more source