Results 31 to 40 of about 1,013,866 (199)

Projected pH reductions by 2100 might put deep North Atlantic biodiversity at risk [PDF]

, 2014
This study aims to evaluate the potential for impacts of ocean acidification on North Atlantic deep-sea ecosystems in response to IPCC AR5 Representative Concentration Pathways (RCPs).
Barry, J., Bopp, L., Doney, S.C., Dunne, J.P., Gehlen, M., Heinze, C., Jones, D.O.B., Joos, F., Orr, J.C., Resplandy, L., Roth, R., Roy, T., Segschneider, J., Séférian, R., Tjiputra, J.   +14 more
core   +7 more sources

Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets [PDF]

, 2014
BACKGROUND: Genome-wide microarrays have been useful for predicting chemical-genetic interactions at the gene level. However, interpreting genome-wide microarray results can be overwhelming due to the vast output of gene expression data combined with off-
Christadore, Lisa M., Kolaczyk, Eric D., Pham, Lisa, Schaus, Scott E.   +3 more
core   +1 more source

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]

, 2016
The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela, DI PAOLO, Virginia, Giampaolo, Adele, Gravina, GIOVANNI LUCA, Hassan, Hamisa Jane, Macioce, Giampiero, Marampon, Francesco, Milazzo, Luisa, Tombolini, Vincenzo, Vulcano, Francesca, Zani, Bianca Maria   +10 more
core   +9 more sources

Quantifying the relative importance of land cover change from climate and land use in the representative concentration pathways [PDF]

, 2015
Climate change is projected to cause substantial alterations in vegetation distribution, but these have been given little attention in comparison to land-use in the Representative Concentration Pathway (RCP) scenarios.
Davies-Barnard, T., Jones, C. D., Singarayer, J. S., Valdes, P. J., Wiltshire, A. J.   +4 more
core   +2 more sources

TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation [PDF]

, 2017
Neural activity alters osmotic gradients favoring cell swelling in retinal Müller cells. This swelling is followed by a regulatory volume decrease (RVD), partially mediated by an efflux of KCl and water. The transient receptor potential channel 4 (TRPV4),
Capurro, Claudia Graciela, Di Giusto, Gisela, Fernández, Juan, Ford, Paula, Kalstein, Maia, Netti, Vanina Alejandra, Pizzoni, Alejandro, Rivarola, Valeria   +7 more
core   +1 more source

Future changes in global warming potentials under representative concentration pathways

Environmental Research Letters, 2011
Global warming potentials (GWPs) are the metrics currently used to compare emissions of different greenhouse gases under the United Nations Framework Convention on Climate Change. Future changes in greenhouse gas concentrations will alter GWPs because the radiative efficiencies of marginal changes in CO2, CH4 and N2O depend on their background ...
Reisinger, A., Meinshausen, M., Manning, M.   +2 more
openaire   +2 more sources

Beyond shared socioeconomic pathways (SSPs) and representative concentration pathways (RCPs): climate policy implementation scenarios for Europe, the US and China [PDF]

Climate Policy, 2020
The 2015 Paris Agreement is falling short of its aspirations, as signatory countries are struggling to implement the policies required to meet the targets.
Hewitt, Richard J., Cremades, Roger, Kovalevsky, Dmitry V., Hasselmann, Klaus   +3 more
openaire   +3 more sources

Projection of Air Pollution in Northern China in the Two RCPs Scenarios

Remote Sensing, 2021
Air pollution in North China (NC) is an important issue affecting the economy and health. In this study, we used a regional climate model, the Weather Research and Forecasting Model with Chemistry (WRF-Chem) to project air pollution in NC and investigate
Chengrong Dou, Zhenming Ji, Yukun Xiao, Zhiyuan Hu, Xian Zhu, Wenjie Dong   +5 more
doaj   +1 more source

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in ...
Arcaro, Alexandre, Castelletti, Deborah, Fu, Xuebin, Liu, Yang, Mischak, Harald, Mullen, William, Pejchinovski, Martin, Serra, Andreas L., Siwy, Justyna, Wang, Xueqi, Watnick, Terry J.   +10 more
core   +2 more sources

The global and regional impacts of climate change under representative concentration pathway forcings and shared socioeconomic pathway socioeconomic scenarios [PDF]

Environmental Research Letters, 2019
Abstract This paper presents an evaluation of the global and regional consequences of climate change for heat extremes, water resources, river and coastal flooding, droughts, agriculture and energy use. It presents change in hazard and resource base under different rates of climate change (representative concentration pathways (RCP ...
N W Arnell, J A Lowe, D Bernie, R J Nicholls, S Brown, A J Challinor, T J Osborn   +6 more
openaire   +8 more sources