Results 31 to 40 of about 1,464,875 (247)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Information, Polarization and Delegation in Democracy. [PDF]
This paper investigates the merits of different democratic institutions when politics is uni-dimensional, there is uncertainty both about the preferences of the future electorate and the future polarization of political parties, and politicians have ...
Christian Schultz
core +2 more sources
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Do we really need politicians? : e-democracy vs. representative democracy
, 2019 This contribution was delivered on the occasion of the EUI State of the Union in Florence on 02 May 2019Do we really need politicians? E-democracy vs.
PÖTTERING, Hans-Gert +2 more
core +1 more source
Contemporary Forms of Representative Democracy
Anali Hrvatskog Politološkog Društva, 2007 In this paper, the author examines contemporary forms of representative democracy in the light of three theoretical and ideological conflicts. The first conflict concerns those who strive for a consolidated representative democracy, and develop theories ...
Klaus von Beyme
doaj
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Populism as a narrative and the crisis of representative democracy
Revista CIDOB d'Afers Internacionals, 2018 In this article a critical analysis is made of some of the most influential approaches to contemporary populism and an alternative hypothesis is proposed.
Camil Ungureanu, Ivan Serrano
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Revista da Faculdade de Direito UFPR, 2015 Due to globalization, the state lost its monopoly on political mediation. For example, it began to share decisions with multiple stakeholders, internal and external, and is not able to control several variables that interfere in national life.
Murilo Gaspardo
doaj +1 more source
Transylvanian Review of Administrative Sciences, 2020 In the recent years we have witnessed the growing criticism of the representative framework and the way it operates in many European countries. At the local level, numerous authorities try to answer the shortcomings of representation by applying new ...
Katarzyna Radzik-Maruszak +2 more
doaj +1 more source