Results 51 to 60 of about 357,026 (288)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

City Councils in Philadelphia and Other Major Cities: Who Holds Office, How Long They Serve, and How Much It All Costs [PDF]

, 2011
Compares the budget, staffing, salaries, electoral conditions, tenure, and representativeness in terms of race/ethnicity and gender of Philadelphia's current city council members with those of past decades and those of fourteen other ...

core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Representativeness and Diversity in Photos via Crowd-Sourced Media Analysis [PDF]

, 2012
In this paper we present a hybrid three steps mechanism for automated-human media analysis employed for selecting a small number of representative and diverse images in the context of a noisy set of images.
Anca-Livia, Radu, Giunchiglia, Fausto, Ionescu, Bogdan, Menéndez, María, Stöttinger, Julian   +4 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A pattern of Romanian presidential mechanism

Sfera Politicii, 2015
The paper proposes a comparative analysis of the 2014 presidential election with the previous six to outline a pattern of Romanian electoral practice in the field.
Alexandru Radu
doaj  

Do Representatives Represent you?

Integrative Journal of Nursing and Health, 2019
Introduction: Representation by a small group of chosen representatives is a common used strategy for decision making within a large heterogeneous group of people. In hospital and first-line setting, we measured the level of representatives-peers agreement for representatives that were selectively chosen by peers and those that were randomly selected ...
Lemmens S, Lopes van Balen V, De Vries R, Scheepers L, Spaanderman M   +4 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Advances in upscaling of eddy covariance measurements of carbon and water fluxes [PDF]

, 2012
Eddy covariance flux towers provide continuous measurements of ecosystem-level net exchange of carbon, water, energy, and other trace gases between land surface and the atmosphere.
Chen, Jiquan, Davis, Kenneth J., Reichstein, Markus, Xiao, Jingfeng   +3 more
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source