Results 81 to 90 of about 357,026 (288)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Getting past diversity in assessing virtual library designs
Journal of the Brazilian Chemical Society, 2002 A great deal of effort is currently going into the design of combinatorial libraries. Published approaches are generally "optimal" in that each best satisfies the target objective function it employs.
Clark Robert D.
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Representativeness of the European Social Partner Organizations: Tanning and Leather Industry [PDF]
, 2017 This study provides information designed to encourage sectoral social dialogue in the tanning and leather sector. The aim of Eurofound’s series of studies on representativeness is to identify the relevant national and supranational social partner ...
Adam, Georg, Allinger, Bernadette
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Modernization Without Change: Decision-Making Process in the Mercosur Parliament [PDF]
Brazilian Political Science Review, 2016 This article analyzes the role of Mercosur's Parliament within Mercosur’s institutional design and decision-making process by associating its institutional arrangements to potential outcomes over representativeness.
Marcelo de Almeida Medeiros +2 more
doaj
Representativeness of the FADN CZ sample of agricultural enterprises and ways of its verification
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013 Following accession to the European Union, Czech Republic joined the EU FADN system. The Farm Accountancy Data Network (FADN) is the main EC information source on real economic situation of agricultural enterprises.
Marie Prášilová +2 more
doaj +1 more source
Possible errors in establishing the sample dimensions of survey investigations [PDF]
Starting from the „rough” use of 1,500-1,800 subject samples in field researches with populations of the dimensions of a medium town, a capital or an entire country, which generates doubts and possible questions related to the representativeness of the ...
Alexandru ISAIC-MANIU, Irina M. DRĂGAN
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source