Results 251 to 260 of about 616,462 (316)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Patient and public perceptions of involvement and engagement in healthcare research: a descriptive exploratory qualitative study in Hong Kong. [PDF]

Res Involv Engagem
Li Y, Lu W, Ho EKY, Takemura N, Li M, Li M, Wray J, Yorke J.   +7 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Post-discharge "continuum of care" clinical pathway (CP) for persons with severe neuro-disabilities - qualitative research to model needs-based community healthcare, capture the real-life care situation, and assess the appropriateness of the CP's concept with input from community- and hospital-based healthcare professionals. [PDF]

Front Neurol
Reichl S, Roschka S, Einhäupl B, Götze D, Schössow C, Bender A, Platz T.   +6 more
europepmc   +1 more source

Governance and Update Process for Lifestyle Medicine Core Competencies and Definitions. [PDF]

Am J Lifestyle Med
Rea BL, Cheema S, Lanza S, Makinde MT, Matthews S, Palma M, Kadosh MA, Lapsa-Lešinske A, Karlsen MC.   +8 more
europepmc   +1 more source

Generative AI voting: fair collective choice is resilient to LLM biases and inconsistencies. [PDF]

EPJ Data Sci
Majumdar S, Elkind E, Pournaras E.
europepmc   +1 more source

What patients value in data reuse for oncology research: a multi-stakeholder qualitative study to inform the European Health Data Space implementation in Belgium and beyond. [PDF]

Arch Public Health
Lalova-Spinks T, van Zeeland I, Léonard S, Horicks F, Taels B, de la Cruz PC, Bax L, Carton B, Dirkx W, Shabani M.   +9 more
europepmc   +1 more source

Supporting breast and cervical cancer screening follow-up: qualitative health plan interviews. [PDF]

BMC Health Serv Res
Lin B, Gruschow K, Burke A, Zhou X, Richards TB, Byron SC.   +5 more
europepmc   +1 more source