Results 171 to 180 of about 405,671 (296)

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Genome-scale CRISPRi screen identifies pcnB repression conferring improved physiology for overproduction of free fatty acids in Escherichia coli. [PDF]

Nat Commun
Fang L, Hao X, Fan J, Liu X, Chen Y, Wang L, Huang X, Song H, Cao Y.   +8 more
europepmc   +1 more source

TWO SEQUENTIAL REPRESSIONS OF DNA SYNTHESIS IN THE ESTABLISHMENT OF LYSOGENY BY PHAGE P22 AND ITS MUTANTS

, 1964
Hamilton O. Smith, Myron Levine
openalex   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

A rapid and efficient strategy for combinatorial repression of multiple genes in Escherichia coli. [PDF]

Microb Cell Fact
Zheng Y, Mo Y, Yuan Y, Su T, Qi Q.
europepmc   +1 more source

The repression and induction by thyroxin of hemoglobin synthesis during amphibian metamorphosis.

, 1965
Bernard Moss, Vernon M. Ingram
openalex   +1 more source

Intracellular concentration of cysteine in Escherichia coli and its relation to repression of the sulphate-activating enzymes [PDF]

, 1967
J.F. Wheldrake
openalex   +1 more source

A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility

Advanced Science, EarlyView.
This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.
Dong Yan, Jie Huang, Fengqi Tian, Haidong Shu, Han Chen, Qian Peng, Hongwei Wu, Jianlong Zhao, Anireddy S. N. Reddy, Gang Li, Yuanchao Wang, Suomeng Dong   +11 more
wiley   +1 more source

Melatonin Mitigates Cd-Induced Growth Repression and RNA m⁶A Hypermethylation by Triggering MMR-Mediated DNA Damage Response. [PDF]

Plants (Basel)
Tang Z, Wang H, Wang X, Ludlow RA, Liu Z, Zhang M, Cao Q, Liu W, Zhao Q.   +8 more
europepmc   +1 more source

Repression and induction of arylsulphatase synthesis in Aerobacter aerogenes [PDF]

, 1964
T Harada, B. Spencer
openalex   +1 more source